表观扩散系数对淋巴瘤与良性病变的鉴别作用meta分析

发布时间：2018-08-03 19:17

【摘要】：目的对涉及淋巴瘤与良性病变在扩散加权成像中的应用进行文献复习汇总,定量评价表观扩散系数(ADC)值的鉴别作用。方法检索Pubmed、中国生物医学文献数据库、中国学术期刊网全文数据库、万方数据库、Embase 2004年到2016年公开发表的中、英文文献,按照统一的纳入及排除标准筛选文献,提取出相关参数及ADC值的平均值和标准差,汇总标准化均数差(SMD)及其95%可信区间。结果共纳入27篇文献,其中英文12篇,中文15篇,所有纳入文献的淋巴瘤与良性病变ADC的SMD为-2.25(-2.62,-1.89),对发生部位进行亚组分析,发生于中枢神经系统的淋巴瘤与良性病变ADC的SMD为-1.98(-2.65,-1.32),发生于全身淋巴结者为-2.44(-2.81,-2.07);对场强大小进行亚组分析,1.5 T下淋巴瘤与良性病变ADC的SMD为-2.28(-2.69,-1.87),3.0 T下为-2.22(-3.03,-1.40)。所有SMD结果均有统计学意义。结论 ADC可以用于淋巴瘤与良性病变的鉴别,并且淋巴瘤的ADC值更低。
[Abstract]:Objective to review the literature on the application of lymphoma and benign lesions in diffusion-weighted imaging and to evaluate quantitatively the differential value of diffusion coefficient (ADC). Methods Pubmed, China Biomedical Literature Database, full text Database of China academic Journals Network, Embase database of Wanfang, published in Chinese and English from 2004 to 2016, were searched and selected according to the unified inclusion and exclusion criteria. The average and standard deviation of relevant parameters and ADC values were extracted, and the normalized mean difference (SMD) and its 95% confidence interval were summarized. Results A total of 27 articles were included, including 12 in Chinese and 12 in Chinese, and 15 in Chinese. The SMD of ADC of lymphoma and benign lesions was -2.25 (-2.62 ~ 1.89). The SMD of ADC in central nervous system lymphoma and benign lesions was -1.98 (-2.65 ~ 1.32), and that in systemic lymph nodes was -2.44 (-2.81 ~ 2.07), the SMD of lymphoma and benign lesion ADC was -2.28 (-2.69 -1.87) 3.0T (-3.03 ~ 1.40). All SMD results were statistically significant. Conclusion ADC can be used to differentiate lymphoma from benign lesions, and the ADC value of lymphoma is lower.
【作者单位】：暨南大学附属第一医院影像中心;
【分类号】：R445.2;R733.1

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