化湿和胃饮防治含顺铂化疗后湿阻中焦型恶心呕吐的临床研究
发布时间：2018-08-04 11:27
【摘要】：研究目的:观察总结化湿和胃饮联合西医治疗对于含顺铂化疗后湿阻中焦型恶心呕吐的疗效和安全型。研究方法:1、入组病例,分为对照组:单纯使用西医治疗,本文主要通过地塞米松5mg+帕洛诺司琼0.25mg治疗呕吐,及实验组:在对照组的基础上加用化湿和胃饮,各30例。2、患者含顺铂化疗同时服用化湿和胃饮联合西医治疗,与单纯西医治疗一周内恶心呕吐的相关中医及FLIE评分。化湿和胃饮由昆山市中医医院煎药器统一浓煎,分2次口服,早晚各100ml。西医化疗方案包括:TP(紫杉醇135～175mg/m2+顺铂75mg/m2)、DP(多西他赛 75mg/m2+顺铂 75mg/m2)、GP(吉西他滨 1000mg/m2+顺铂 75mg/m2)、NP(长春瑞滨 25-30mg/m2+顺铂 75mg/m2)、GDP(吉西他滨1000mg/m2+顺铂 75mg/m2+地塞米松20mg)。辅以保肝(天晴甘美150mg静滴)和护胃(泮托拉唑40mg静滴)。通过观察临床指标(血常规、肝肾功能),恶心呕吐中医评分及恶心呕吐FLIE评分,分别观察化疗第一、三、五、七天的相关评分,评判化湿和胃饮联合西医治疗在含顺铂化疗后湿阻中焦型恶心呕吐的疗效。3、统计学方法:数据处理采用SPSS统计分析软件,两组对比分析,定性资料采用x2检验,定量资料符合正态分布采用t检验。给出检验统计量及其对应的P值,以P≤0.05作为有统计学意义。结果:1、含顺铂化疗后湿阻中焦型的表现为:恶心呕吐、头重、怠倦、脘闷、腹胀、纳呆、口粘渴、喜饮,舌苔厚白或腻,脉缓等湿阻中焦证表现。化湿和胃饮联合西医治疗对比单纯的西医治疗含顺铂化疗后湿阻中焦型恶心呕吐在长期治疗上有较好的临床疗效。2、化湿和胃饮联合西医治疗相对单纯西医治疗的疗效相对较好,患者能明显改善化疗期间及化疗后的恶心呕吐反应,对于部分单纯西医治疗不易改善的化疗导致的恶心呕吐,化湿和胃饮联合西医治疗有一定的优势,能增加患者的耐受程度。3、化湿和胃饮联合西医治疗含顺铂化疗后湿阻中焦证恶心呕吐在临床指标方面,相对于单纯西医治疗含顺铂化疗后湿阻中焦型恶心呕吐无明显差异,不存在其他的副反应。通过本研究,我们可以看出化湿和胃饮对于化疗后湿阻中焦证恶心呕吐存在较好的治疗作用,化湿和胃饮有利于化疗后湿阻中焦证恶心呕吐的辅助治疗。结论:化湿和胃饮联合西医治疗相对于单纯西医治疗存在一定的优势。
[Abstract]:Objective: to observe the efficacy and safety of Huashi-Wei-Yin combined with western medicine in treating nausea and vomiting with dampness resistance and middle scorch after chemotherapy with cisplatin. Methods the patients were divided into control group and control group. The patients were treated with western medicine alone. The patients in the experimental group were treated with dexamethasone 5mg paronosetron 0.25mg, and the experimental group was treated with Huazhi and Weiyin on the basis of the control group. The patients were treated with cisplatin chemotherapy combined with Huashi and Weiyin combined with western medicine, and the related TCM and FLIE scores of nausea and vomiting within one week of treatment with western medicine alone. Dehumidification and stomach drink by Kunshan traditional Chinese Medicine Hospital decoction unit unified concentrated, divided into 2 oral, in the morning and evening 100 ml. The chemotherapy regimen of western medicine included 135~175mg/m2 (paclitaxel 135~175mg/m2 cisplatin 75mg/m2) DP (docetaxel 75mg/m2 cisplatin 75mg/m2) GP (gemcitabine 1000mg/m2 cisplatin 75mg/m2) NP (vinorelbine 25-30mg/m2 cisplatin 75mg/m2) and gemcitabine 1000mg/m2 cisplatin 75mg/m2 dexamethasone 20mg. It was supplemented with liver protection (150mg intravenous drip) and stomach protection (pam Tora 40mg intravenous drip). By observing clinical indexes (blood routine, liver and kidney function), TCM score of nausea and vomiting and FLIE score of nausea and vomiting, the correlation scores of the first, third, fifth and seventh days of chemotherapy were observed respectively. To evaluate the curative effect of Huashi and Weiyin combined with western medicine in treating nausea and vomiting with dampness resistance and middle scorch after chemotherapy with cisplatin. Statistical method: the data were processed by SPSS statistical analysis software, the two groups were compared and analyzed, the qualitative data were analyzed by x2 test. The quantitative data were consistent with normal distribution by t test. The test statistics and their corresponding P values are given, with P 鈮，
本文编号：2163842
[Abstract]:Objective: to observe the efficacy and safety of Huashi-Wei-Yin combined with western medicine in treating nausea and vomiting with dampness resistance and middle scorch after chemotherapy with cisplatin. Methods the patients were divided into control group and control group. The patients were treated with western medicine alone. The patients in the experimental group were treated with dexamethasone 5mg paronosetron 0.25mg, and the experimental group was treated with Huazhi and Weiyin on the basis of the control group. The patients were treated with cisplatin chemotherapy combined with Huashi and Weiyin combined with western medicine, and the related TCM and FLIE scores of nausea and vomiting within one week of treatment with western medicine alone. Dehumidification and stomach drink by Kunshan traditional Chinese Medicine Hospital decoction unit unified concentrated, divided into 2 oral, in the morning and evening 100 ml. The chemotherapy regimen of western medicine included 135~175mg/m2 (paclitaxel 135~175mg/m2 cisplatin 75mg/m2) DP (docetaxel 75mg/m2 cisplatin 75mg/m2) GP (gemcitabine 1000mg/m2 cisplatin 75mg/m2) NP (vinorelbine 25-30mg/m2 cisplatin 75mg/m2) and gemcitabine 1000mg/m2 cisplatin 75mg/m2 dexamethasone 20mg. It was supplemented with liver protection (150mg intravenous drip) and stomach protection (pam Tora 40mg intravenous drip). By observing clinical indexes (blood routine, liver and kidney function), TCM score of nausea and vomiting and FLIE score of nausea and vomiting, the correlation scores of the first, third, fifth and seventh days of chemotherapy were observed respectively. To evaluate the curative effect of Huashi and Weiyin combined with western medicine in treating nausea and vomiting with dampness resistance and middle scorch after chemotherapy with cisplatin. Statistical method: the data were processed by SPSS statistical analysis software, the two groups were compared and analyzed, the qualitative data were analyzed by x2 test. The quantitative data were consistent with normal distribution by t test. The test statistics and their corresponding P values are given, with P 鈮，
本文编号：2163842
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