经鼻蝶窦入路垂体腺瘤切除术后复发的相关影响因素分析

发布时间：2018-08-16 16:13

【摘要】：目的:本研究旨在探讨与垂体腺瘤术后复发相关影响因素,从而对垂体腺瘤术后复发的防治提供的参考,以减少术后复发。研究方法:回顾性分析自2010年1月至2016年1月宁夏医科大学总医院神经外科收治的99例经鼻蝶窦入路手术治疗的垂体腺瘤患者临床资料,收集其性别、年龄、临床症状、肿瘤的大小、侵袭性、垂体卒中、手术全切情况、术后残余、Ki-67等临床资料。结果:本组研究中复发26例,复发率为26.26%。对影响复发的11项指标进行单因素分析得出肿瘤的侵袭性、大小、全切情况及术后残留这四项指标是影响垂体腺瘤术后复发的相关因素(P0.05)。再将这四项指标进行Logistic回归分析得出肿瘤侵袭性、术后残留为垂体腺瘤术后复发的独立危险因素。同时,垂体腺瘤的侵袭性以及术后残留β值0,说明这两种是促进垂体腺瘤术后复发的因素,而肿瘤存在侵袭性则是经影响患者术后复发的主要风险因素。结论:多种因素的综合作用导致了垂体腺瘤的术后复发,肿瘤侵袭性、术后残留与术后复发明确相关。了解肿瘤性质,术中尽可能提高肿瘤切除率、减少术后残余,可以降低垂腺瘤术后复发率。
[Abstract]:Objective: to investigate the factors related to postoperative recurrence of pituitary adenomas, and to provide references for the prevention and treatment of postoperative recurrence of pituitary adenomas. Methods: the clinical data of 99 patients with pituitary adenoma treated by transsphenoidal approach from January 2010 to January 2016 in Neurosurgery Department of General Hospital of Ningxia Medical University were retrospectively analyzed, and their sex, age, clinical symptoms were collected. Tumor size, invasion, pituitary apoplexy, total resection, postoperative residual Ki-67 and other clinical data. Results: there were 26 cases of recurrence in this study, and the recurrence rate was 26.26%. The single factor analysis showed that the invasiveness, size, total resection and postoperative residue of the tumor were the related factors of postoperative recurrence of pituitary adenoma (P0.05). The Logistic regression analysis showed that the tumor invasiveness was the independent risk factor of postoperative recurrence of pituitary adenoma. At the same time, the invasiveness of pituitary adenoma and the residual 尾 value of pituitary adenoma were 0, which indicated that these two kinds of factors could promote the recurrence of pituitary adenoma, and the invasiveness of tumor was the main risk factor of postoperative recurrence of pituitary adenoma. Conclusion: the combined effects of various factors lead to postoperative recurrence of pituitary adenoma, tumor invasiveness, postoperative residual and postoperative recurrence. To understand the nature of the tumor, to improve the tumor resection rate and reduce the postoperative residual, can reduce the recurrence rate of adenoma.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R736.4

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