Hippo信号通路在肺癌中的研究进展

发布时间：2018-08-21 13:23

【摘要】：肺癌是全世界范围内肿瘤相关性死亡的首要原因,每年死亡人数超过100万人,占全球癌症死亡人数的五分之一。虽然目前在手术、放化疗、靶向治疗、免疫治疗肺癌方面取得了一定进展,但患者的预后仍不理想。因此,亟待寻找评价预后的分子标志物和肺癌的治疗新靶点,为肺癌患者提供生存获益的有效方法。近年来,Hippo信号通路逐渐成为国内外肿瘤研究领域中新兴且热门的研究方向。Hippo信号通路激活时,其核心组件MST/MOB、LATS1/2等能抑制转录的共激活剂YAP/TAZ的转录,二者被磷酸化并滞留在细胞浆中,从而抑制肺癌的发生发展。因此Hippo信号通路在临床应用中的潜在价值也越来越受关注。本篇文章总结了Hippo信号通路核心组成元件及上下游调控因子在肺癌形成进展过程中的重要作用和分子机制,并对Hippo信号通路的研究前景进行展望。
[Abstract]:Lung cancer is the leading cause of tumor-related deaths worldwide, accounting for more than 1 million deaths each year, accounting for 1/5 of the world's cancer deaths. Although some progress has been made in surgery, radiotherapy, chemotherapy, targeted therapy and immunotherapy for lung cancer, the prognosis of the patients is still not satisfactory. Therefore, it is urgent to search for molecular markers for evaluating prognosis and new therapeutic targets for lung cancer, so as to provide an effective way for lung cancer patients to survive and benefit. In recent years, Hippo signaling pathway has gradually become a new and popular research direction in the field of tumor research at home and abroad. When the Hippo signaling pathway is activated, its core component, MST / MOBX LATS1 / 2, can inhibit the transcription of YAP/TAZ, a transcriptional co-activator. They are phosphorylated and remain in the cytoplasm, thereby inhibiting the development of lung cancer. Therefore, the potential value of Hippo signaling pathway in clinical application has been paid more and more attention. This paper summarizes the important role and molecular mechanism of the core components and upstream and downstream regulatory factors of Hippo signaling pathway in the process of lung cancer formation and progression, and prospects for the research of Hippo signaling pathway.
【作者单位】：哈尔滨医科大学附属肿瘤医院内四科;
【基金】：国家自然科学基金面上项目(No.81772474)资助~~
【分类号】：R734.2

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