乳腺癌组织中SOX4、EZH2的表达及临床意义
发布时间：2018-08-29 18:11
【摘要】：目的观察上皮-间质转化(epithelial-mesenchymal transition,EMT)调控因子SOX4和EZH2在乳腺癌组织中的表达,探讨两者的临床意义。方法采用免疫组化En Vision两步法检测241例乳腺癌组织及126例癌旁非肿瘤乳腺组织中SOX4、EZH2的表达,分析两者表达的相关性及其与乳腺癌临床病理特征的关系。结果乳腺癌组织中SOX4的高表达率为82.2%,显著高于癌旁非肿瘤乳腺组织的高表达率(57.1%,P0.05);EZH2在乳腺癌组织中的高表达率为80.1%,显著高于癌旁非肿瘤乳腺组织的高表达率(47.6%,P0.05)。SOX4高表达与肿瘤淋巴结转移、TNM高分期、HER-2高表达相关(P0.05);EZH2高表达与肿瘤组织学高分级、淋巴结转移、ER阴性、EGFR阳性、Ki-67高增殖指数相关(P0.05),并与SOX4表达呈显著正相关(rs=0.256,P0.001)。结论 EMT调控因子SOX4和EZH2在乳腺癌组织中表达上调,两者可能共同参与乳腺癌的转移,有望成为预测乳腺癌转移的潜在生物学标志物。
[Abstract]:Objective to investigate the expression of epithelial-interstitial transformation (epithelial-mesenchymal transition,EMT) regulatory factors SOX4 and EZH2 in breast cancer and to explore their clinical significance. Methods Immunohistochemical En Vision two-step method was used to detect the expression of SOX4,EZH2 in 241 cases of breast cancer and 126 cases of non-cancerous breast tissues adjacent to carcinoma. The relationship between the expression of SOX4,EZH2 and clinicopathological features of breast cancer was analyzed. Results the high expression rate of SOX4 in breast cancer tissues was 82.2, which was significantly higher than that in non-cancerous breast tissues adjacent to cancer (57.1% P0.05). The high expression rate of EZH2 in breast cancer tissues was 80.1, which was significantly higher than that in non-tumor adjacent breast tissues (47.6%). The high expression of EZH2 was associated with the high expression of HER-2 in tumor lymph node metastasis and TNM high stage (P0.05), and the high expression of EZH2 was associated with the high grade of tumor histology. The expression of Ki-67 was positively correlated with the expression of SOX4 (rs=0.256,P0.001) and ER negative in lymph node metastasis (P0.05). Conclusion the expression of EMT regulatory factors SOX4 and EZH2 is up-regulated in breast cancer tissues. Both of them may be involved in the metastasis of breast cancer and may be a potential biomarker for predicting breast cancer metastasis.
【作者单位】： 安徽医科大学病理学教研室;
【基金】：国家自然科学基金(81372476、81472493)
【分类号】：R737.9
本文编号：2212003
[Abstract]:Objective to investigate the expression of epithelial-interstitial transformation (epithelial-mesenchymal transition,EMT) regulatory factors SOX4 and EZH2 in breast cancer and to explore their clinical significance. Methods Immunohistochemical En Vision two-step method was used to detect the expression of SOX4,EZH2 in 241 cases of breast cancer and 126 cases of non-cancerous breast tissues adjacent to carcinoma. The relationship between the expression of SOX4,EZH2 and clinicopathological features of breast cancer was analyzed. Results the high expression rate of SOX4 in breast cancer tissues was 82.2, which was significantly higher than that in non-cancerous breast tissues adjacent to cancer (57.1% P0.05). The high expression rate of EZH2 in breast cancer tissues was 80.1, which was significantly higher than that in non-tumor adjacent breast tissues (47.6%). The high expression of EZH2 was associated with the high expression of HER-2 in tumor lymph node metastasis and TNM high stage (P0.05), and the high expression of EZH2 was associated with the high grade of tumor histology. The expression of Ki-67 was positively correlated with the expression of SOX4 (rs=0.256,P0.001) and ER negative in lymph node metastasis (P0.05). Conclusion the expression of EMT regulatory factors SOX4 and EZH2 is up-regulated in breast cancer tissues. Both of them may be involved in the metastasis of breast cancer and may be a potential biomarker for predicting breast cancer metastasis.
【作者单位】： 安徽医科大学病理学教研室;
【基金】：国家自然科学基金(81372476、81472493)
【分类号】：R737.9
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