外周血甲基化Septin-9检测对结直肠癌诊断价值的Meta分析

发布时间：2018-09-04 15:45

【摘要】：目的:Meta系统性评价Septin-9在结直肠癌中的诊断价值。方法:检索Pub Med、生物医学外文全文服务系统、Ovid、中国学术期刊全文数据库、中国生物医学文献数据库、维普中文科技期刊数据库、万方数据库,日期截止至2017年1月。严格按照纳入和排除标准筛选文献,并依据QUADAS标准对文献进行质量评估。使用双变量Meta模型合并检验效能分析,通过Q检验、I2检验检测研究异质性,通过亚组分析、敏感性分析探讨异质性来源,通过Deek's漏斗图评估发表偏移。结果:共纳入11篇文献;Septin-9诊断结直肠癌的合并敏感度为0.70(95%CI:0.67~0.72),合并特异度为0.91(95%CI:0.90~0.92),诊断比值比为28.76(95%CI:17.70~46.75),SROC的曲线下面积(AUC)为0.922 1。异质性检验提示不存在阈值效应,但存在其他因素引起的异质性。通过敏感性分析发现纳入文献中有一个离群值。亚组分析结果显示,根据1/3判为阳性和2/3判为阳性分组:AUC为0.939 7比0.826 5。根据亚洲人种和欧美人种分组:AUC为0.936 8比0.921 0。Deek's漏斗图评估纳入文献不存在发表偏倚。结论:外周血甲基化Septin-9诊断结直肠癌的整体准确性较高,可作为一项很好的指标用于结直肠癌诊断。
[Abstract]:Objective to evaluate the diagnostic value of Septin-9 in colorectal cancer systematically. Methods: Pub Med, Biomedical Foreign language Full-text Service system (Ovid), Chinese academic Journal Full-text Database, Chinese Biomedical Literature Database, Weipu Chinese Sci-tech Journal Database and Wanfang Database were searched. The literature was screened according to the inclusion and exclusion criteria, and the quality of the literature was evaluated according to QUADAS criteria. The heterogeneity is studied by using bivariate Meta model combination test effectiveness analysis, Q test I2 test, subgroup analysis, sensitivity analysis, and Deek's funnel map evaluation. Results: the combined sensitivity and specificity were 0.70 (95%CI:0.67~0.72) and 0.91 (95%CI:0.90~0.92), respectively. The area under the curve of the ratio of diagnosis to diagnosis was 28.76 (95%CI:17.70~46.75) and the area under the curve (AUC) was 0.922. Heterogeneity test showed that there was no threshold effect, but there was heterogeneity caused by other factors. Sensitivity analysis revealed that there was an outlier in the literature. Subgroup analysis showed that 1 / 3 was positive and 2 / 3 was positive, with a score of 0.939 7 to 0.826 5. There was no publication bias in the literature according to the 0.Deek's funnel assessment of Asian and European races with a score of 0.936 8 to 0.921. Conclusion: the overall accuracy of peripheral blood methylated Septin-9 in the diagnosis of colorectal cancer is high and can be used as a good index for the diagnosis of colorectal cancer.
【作者单位】：福建省肿瘤医院检验科/福建医科大学附属肿瘤医院检验科/福建省肿瘤生物治疗重点实验室;
【分类号】：R735.34

【相似文献】