胃肠道间质瘤骨转移的研究进展

发布时间：2018-09-04 15:54

【摘要】：胃肠道间质瘤(gastrointestinal stromal tumor,GIST)是最常见的胃肠道间质源性肿瘤,最常发生于胃,其次为小肠。然而,胃肠道间质瘤骨转移的病例极为少见。目前为止,中英文文献报道的GIST骨转移仅17例。本文通过对相关文献进行综述发现,17例患者出现骨转移的平均年龄约为61.59岁。大部分患者表现为骨的多发转移,涉及的部位主要有脊柱、肋骨、骨盆、肱骨、股骨等,脊柱仍是GIST骨转移最常见的部位。GIST骨转移患者的平均生存时间超过48.35个月,转移病灶经手术切除和非手术切除的预后时间分别为60.38个月和37.67个月;转移病灶采用手术切除联合使用靶向药物与其他治疗方式相比,平均预后时间分别为73.17个月和34.82个月。GIST出现骨转移时的年龄不同,患者的预后也不同:60岁及60岁者平均预后时间分别为62.11个月和32.88个月。本研究认为,手术切除应作为GIST骨转移首选的治疗方式,术后及早联合伊马替尼等进行靶向治疗,可提高患者的生活质量,延长生存期。
[Abstract]:Gastrointestinal stromal tumor (gastrointestinal stromal tumor,GIST) is the most common mesenchymal tumor of the gastrointestinal tract, most often occurring in the stomach, followed by the small intestine. However, bone metastases from gastrointestinal stromal tumors are rare. So far, only 17 cases of GIST bone metastasis have been reported in Chinese and English literature. The average age of bone metastasis in 17 patients was about 61.59 years old. Most of the patients showed multiple metastases of bone. The main sites involved included spine, ribs, pelvis, humerus, femur, etc. The average survival time of patients with GIST bone metastasis was more than 48.35 months. The prognostic time of surgical resection and non-operative resection were 60.38 months and 37.67 months, respectively. The mean prognostic time was 73.17 months and 34.82 months, respectively. The mean prognostic time was 62.11 months and 32.88 months, respectively. This study suggests that surgical resection should be the first choice for the treatment of GIST bone metastasis. Early targeted therapy combined with imatinib can improve the quality of life and prolong the survival time of the patients.
【作者单位】：上海长征医院骨科;
【分类号】：R735

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