奥沙利铂治疗结直肠癌所致神经毒性的相关因素分析

发布时间：2018-09-06 06:37

【摘要】：目的:观察奥沙利铂治疗结直肠癌所致神经毒性的发生情况,对导致神经毒性的相关高危因素进行分析,为神经毒性的预防提供参考意见。方法:对109例接受奥沙利铂化疗的结直肠癌患者的病例进行回顾性分析,记录患者神经毒性的发生情况及患者机体指标、化疗相关指标、血常规、血生化相关检验指标,用统计学方法筛选出导致神经毒性的高危因素。结果:全部109例患者中,共有84例患者在接受奥沙利铂治疗后出现神经毒性,总体发生率为77.1%,具体分析各项指标,发现患者的肿瘤分期、体表面积、化疗周期数、奥沙利铂累积剂量、化疗后血小板的变化、化疗后血钙的变化等6项指标有统计学意义(P0.05),是导致神经毒性的高危因素。结论:奥沙利铂治疗结直肠癌过程中,神经毒性发生率较高,对于合并相关高危因素的患者应给予重视,密切观察患者发生神经毒性的情况,必要时给予积极预防及治疗措施。
[Abstract]:Aim: to observe the occurrence of neurotoxicity induced by oxaliplatin in the treatment of colorectal cancer and to analyze the related high risk factors of neurotoxicity in order to provide reference for the prevention of neurotoxicity. Methods: 109 patients with colorectal cancer received oxaliplatin chemotherapy were retrospectively analyzed. High risk factors for neurotoxicity were screened by statistical method. Results: of the 109 patients, 84 had neurotoxicity after oxaliplatin treatment, and the overall incidence was 77.1. The tumor stage, body surface area and the number of chemotherapy cycles were found by specific analysis. The cumulative dose of oxaliplatin the changes of platelets after chemotherapy and the changes of blood calcium after chemotherapy were statistically significant (P0.05) which were the high risk factors leading to neurotoxicity. Conclusion: the incidence of neurotoxicity in the treatment of colorectal cancer with oxaliplatin is high. Attention should be paid to the patients with associated high risk factors. The neurotoxicity of patients should be observed closely and preventive and therapeutic measures should be taken if necessary.
【学位授予单位】：皖南医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.34

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