1988例甲状腺微小乳头状癌颈部中央区淋巴结转移危险因素分析
发布时间：2018-09-07 11:51
【摘要】：目的:探讨1988例甲状腺微小乳头状癌(PTMC)颈部中央区淋巴结转移的危险因素。方法:回顾性分析新疆医科大学附属肿瘤医院2010-01-2016-03期间初治的PTMC癌患者的临床病理特征,通过χ~2检验、多因素统计分析,探讨颈部中央区淋巴结转移的危险因素。结果:颈部中央区淋巴结转移率为34.9%。单因素分析显示,确诊年龄45岁、男性、多灶、肿瘤位于双侧腺叶(含峡部)、肿瘤直径5mm、包膜浸润、包膜外侵犯是颈部中央区淋巴结转移的危险因素(P0.05);多因素分析显示,男性、确诊年龄45岁、肿瘤直径5mm、包膜浸润、包膜外侵犯是影响颈部中央区淋巴结转移的独立危险因素。肿瘤位置是单灶颈部中央区淋巴结转移的独立危险因素,其中单灶位于腺叶下极者中央区淋巴结转移率最高(46.8%);而多灶肿瘤位置与中央区淋巴结转移无关(P0.05)。结论:当PTMC患者存在以下情况:男性、确诊年龄45岁、肿瘤直径5mm、包膜浸润、包膜外侵犯,单灶位于腺叶下极时,应警惕淋巴结转移可能,建议行积极诊治方案以及更加密切的术后随访。
[Abstract]:Objective: to investigate the risk factors of (PTMC) cervical lymph node metastasis in 1988 cases of thyroid micropapillary carcinoma. Methods: the clinicopathological features of patients with PTMC cancer were analyzed retrospectively from 2010-01-2016-03 in the affiliated Cancer Hospital of Xinjiang Medical University. The risk factors of cervical lymph node metastasis were analyzed by 蠂 ~ 2 test and multivariate statistical analysis. Results: the lymph node metastasis rate in the central region of the neck was 34. 9%. Univariate analysis showed that the age of diagnosis was 45 years old, male with multiple foci, the tumor was located in bilateral lobes of gland (including isthmus), the diameter of tumor was 5mm, the invasion of capsule and extracapsular invasion were the risk factors of lymph node metastasis in the central region of neck (P0.05). The age of diagnosis was 45 years old, tumor diameter was 5 mm, capsule invasion and extracapsular invasion were independent risk factors for cervical lymph node metastasis. The location of tumor was an independent risk factor for lymph node metastasis in the central region of the single focus neck, in which the rate of lymph node metastasis in the central region was the highest (46.8%) in the case of the single focus located in the inferior lobe of the gland, while the location of the multi-focus tumor was not related to the lymph node metastasis in the central region (P0.05). Conclusion: when PTMC patients have the following conditions: male, the age of diagnosis is 45 years, tumor diameter is 5mm, capsule infiltration, extracapsular invasion, single focus is located in the inferior lobe of gland, lymph node metastasis may be possible. It is suggested that active treatment and more closely follow-up should be carried out.
【作者单位】： 新疆医科大学附属肿瘤医院乳腺头颈外科;
【基金】：新疆医科大学研究生创新创业项目(No:CXCY039)
【分类号】：R736.1
[Abstract]:Objective: to investigate the risk factors of (PTMC) cervical lymph node metastasis in 1988 cases of thyroid micropapillary carcinoma. Methods: the clinicopathological features of patients with PTMC cancer were analyzed retrospectively from 2010-01-2016-03 in the affiliated Cancer Hospital of Xinjiang Medical University. The risk factors of cervical lymph node metastasis were analyzed by 蠂 ~ 2 test and multivariate statistical analysis. Results: the lymph node metastasis rate in the central region of the neck was 34. 9%. Univariate analysis showed that the age of diagnosis was 45 years old, male with multiple foci, the tumor was located in bilateral lobes of gland (including isthmus), the diameter of tumor was 5mm, the invasion of capsule and extracapsular invasion were the risk factors of lymph node metastasis in the central region of neck (P0.05). The age of diagnosis was 45 years old, tumor diameter was 5 mm, capsule invasion and extracapsular invasion were independent risk factors for cervical lymph node metastasis. The location of tumor was an independent risk factor for lymph node metastasis in the central region of the single focus neck, in which the rate of lymph node metastasis in the central region was the highest (46.8%) in the case of the single focus located in the inferior lobe of the gland, while the location of the multi-focus tumor was not related to the lymph node metastasis in the central region (P0.05). Conclusion: when PTMC patients have the following conditions: male, the age of diagnosis is 45 years, tumor diameter is 5mm, capsule infiltration, extracapsular invasion, single focus is located in the inferior lobe of gland, lymph node metastasis may be possible. It is suggested that active treatment and more closely follow-up should be carried out.
【作者单位】： 新疆医科大学附属肿瘤医院乳腺头颈外科;
【基金】：新疆医科大学研究生创新创业项目(No:CXCY039)
【分类号】：R736.1
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