HPV感染在咽喉部鳞癌及喉乳头状瘤中的分布研究

发布时间：2018-09-07 18:44

【摘要】：目的人乳头瘤病毒(HPV)被推测为头颈部鳞癌发生、发展的病因。文章旨在研究咽喉部鳞癌、喉乳头状瘤组织中HPV感染型别分布状况及其意义。方法收集自2014年1月至2017年5月间于南京同仁医院耳鼻咽喉头颈外科手术治疗的67例咽喉部鳞癌及喉乳头状瘤患者新鲜组织标本,其中喉癌、下咽癌、口咽癌26例,喉乳头状瘤41例;以同时期手术的良性病变声带息肉20例为对照组。用PCR法进行HPV分型检测。分析受检者HPV肿瘤组感染型别及分布状况。结果研究组67例标本中,HPV阳性者(HPV+)44例(65.7%)。其中喉乳头状瘤的感染型别为HPV11(36/41)和HPV6(4/41),喉癌、下咽癌、口咽癌为HPV16型(6/26),对照组声带息肉HPV均为阴性。结论 HPV16可能是部分喉癌、口咽癌发病的危险因素。喉乳头状瘤的HPV感染率较喉癌、下咽癌更高。
[Abstract]:Objective Human papillomavirus (HPV) is supposed to be the etiology of head and neck squamous cell carcinoma. The purpose of this study was to study the distribution and significance of HPV infection types in laryngeal squamous cell carcinoma and laryngeal papilloma. Methods from January 2014 to May 2017, fresh tissue specimens of 67 patients with laryngeal squamous cell carcinoma and laryngeal papilloma, including laryngeal carcinoma, hypopharyngeal carcinoma and oropharyngeal carcinoma, were collected from 67 patients treated by surgery of otolaryngopharyngeal head and neck surgery in Nanjing Tongren Hospital, including 26 cases of laryngeal carcinoma, hypopharyngeal carcinoma and oropharyngeal carcinoma. 41 cases of laryngeal papilloma and 20 cases of benign vocal cord polyps of the same period were taken as control group. HPV typing was detected by PCR method. The type and distribution of infection in HPV tumor group were analyzed. Results in the study group, 44 cases (65.7%) were (HPV) positive. The infection types of laryngeal papilloma were HPV11 (36 / 41) and HPV6 (4 / 41), laryngeal carcinoma, hypopharyngeal carcinoma, oropharyngeal carcinoma were HPV16 type (6 / 26), and HPV of vocal cord polyp was negative in control group. Conclusion HPV16 may be a risk factor for partial laryngeal carcinoma and oropharyngeal carcinoma. The infection rate of HPV in laryngeal papilloma is higher than that in laryngeal carcinoma and hypopharyngeal carcinoma.
【作者单位】：东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科;
【分类号】：R739.6

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