血管生成抑制蛋白1和结肠癌转移相关蛋白-1在肺鳞状细胞癌中的表达及其临床意义

发布时间：2018-09-11 16:53

【摘要】：目的检测肺鳞状细胞癌(LSCC)中血管生成抑制蛋白1(vasohibin-1)和结肠癌转移相关蛋白-1(MACC1)蛋白的表达及其相互之间的关系,并探讨它们与LSCC患者临床病理因素的关系。方法利用免疫组织化学ElivisionTMplus方法检测160例LSCC和80例正常肺组织中vasohibin-1和MACC1蛋白的表达情况。结果在LSCC组织中,vasohibin-1和MACC1蛋白的表达阳性率分别为59.4%和57.5%;对照组中,vasohibin-1和MACC1蛋白的表达阳性率分别为11.3%和8.8%,其表达差异在两组之间有统计学意义(P0.05)。vasohibin-1和MACC1蛋白的表达阳性率在LSCC患者肿瘤组织的不同分化程度之间、淋巴结转移与否之间以及TNM不同分期之间差异均有统计学意义(P0.05);且vasohibin-1蛋白的表达阳性率与MACC1蛋白的表达阳性率之间呈正相关关系(P0.001)。Kaplan-Meier生存分析表明在LSCC中vasohibin-1和MACC1蛋白阳性表达组患者术后总的生存时间明显低于其阴性组患者,log-rank分析其差异均有统计学意义。多因素回归分析表明vasohibin-1和MACC1蛋白的阳性表达及TNM分期是影响LSCC患者术后生存的独立预后因子。结论异常表达的vasohibin-1和MACC1可能参与了LSCC的发展,并促进其浸润和转移;在LSCC患者中联合检测vasohibin-1和MACC1蛋白的表达对预测其发展和预后均有重要意义。
[Abstract]:Objective to investigate the expression of angiogenesis inhibitor protein 1 (vasohibin-1) and metastasis associated protein 1 (MACC1) in (LSCC) of lung squamous cell carcinoma and their relationship with clinicopathological factors in patients with LSCC. Methods the expression of vasohibin-1 and MACC1 protein in 160 cases of LSCC and 80 cases of normal lung tissue were detected by immunohistochemical ElivisionTMplus method. Results the positive rates of Vasohibin-1 and MACC1 protein were 59.4% and 57.5% in LSCC and 11.3% and 8.8% in control group, respectively. The difference between the two groups was statistically significant (P0.05) .Vasohibin-1 and MACC1 protein were positive. The rate of sex is between the different differentiation degree of tumor tissue in patients with LSCC. There were significant differences between lymph node metastasis and different stages of TNM (P0.05), and there was a positive correlation between the positive rate of vasohibin-1 protein expression and the positive rate of MACC1 protein expression (P0.001) .Kaplan-Meier survival analysis showed that vasohibin-1 and MACC1 eggs were expressed in LSCC. The total survival time of white positive expression group was significantly lower than that of negative group. Multivariate regression analysis showed that the positive expression of vasohibin-1 and MACC1 protein and TNM stage were independent prognostic factors for postoperative survival of LSCC patients. Conclusion the abnormal expression of vasohibin-1 and MACC1 may participate in the development of LSCC and promote its invasion and metastasis. It is important to detect the expression of vasohibin-1 and MACC1 protein in LSCC patients for predicting their development and prognosis.
【作者单位】：蚌埠医学院第一附属医院病理科//蚌埠医学院病理学教研室;
【基金】：安徽省高等学校自然科学研究重点项目(KJ2015A269) 安徽省自然科学基金(1708085MH230) 安徽省高等学校优秀青年人才重点支持计划(gxyq ZD2016160)
【分类号】：R734.2

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