单孔胸腔镜与传统多孔胸腔镜手术治疗肺癌疗效比较的Meta分析
发布时间：2018-09-14 08:24
【摘要】：目的系统评价单孔胸腔镜与传统多孔胸腔镜手术治疗肺癌的临床疗效。方法计算机检索Pub Med、The Cochrane Library(2016年3期)、EMbase、CBM、CNK和Wan Fang Data数据库,搜集单孔胸腔镜与传统多孔胸腔镜手术治疗肺癌的随机对照试验和队列研究,检索时限均为建库至2016年4月。由2位研究员独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果共纳入9个队列研究,1 318例患者。Meta分析结果显示:与传统多孔胸腔镜手术相比,单孔胸腔镜手术治疗肺癌胸腔引流时间更短[MD= 0.70,95%CI( 1.38, 0.02),P=0.04],住院时间更短[MD= 0.52,95%CI( 0.91, 0.14),P=0.007],术中出血量更少[MD= 18.49,95%CI( 33.61, 3.37),P=0.02],术后第1、3天疼痛评分更低[1天:MD= 0.32,95%CI( 0.51, 0.14),P=0.000 7;3天:MD= 0.48,95%CI( 0.58, 0.38),P0.000 01]。但两组在手术时间[MD= 3.40,95%CI( 13.65,6.85),P=0.52]、术后并发症发生率[OR=0.91,95%CI(0.65,1.27),P=0.56]、淋巴结清扫个数[MD= 0.79,95%CI( 2.35,0.77),P=0.32]、住院总费用[MD=0.47,95%CI( 0.39,1.32),P=0.28]、术中中转率[OR=0.92,95%CI(0.44,1.93),P=0.82]及术后第7天疼痛评分[MD= 1.18,95%CI( 2.42,0.07),P=0.06]方面,差异无统计学意义。结论单孔胸腔镜手术治疗肺癌比传统多孔胸腔镜手术在减轻手术创伤方面有一定优势,且手术安全性较好。受纳入研究数量和质量的限制,上述结论仍需开展更多大样本、多中心、长期随访的研究来进行验证。
[Abstract]:Objective to evaluate the clinical effect of single-hole thoracoscopy and traditional multi-hole thoracoscopy in the treatment of lung cancer. Methods the database of Pub Med,The Cochrane Library (2016 (3rd issue) was searched by computer. The randomized controlled trial and cohort study of single hole thoracoscopy and traditional porous thoracoscopic surgery for lung cancer were collected. The retrieval time was established until April 2016. Two researchers independently sifted the literature, extracted the data and evaluated the bias risk in the study, and then used Rev Man 5.3 software to carry out Meta analysis. Results A total of 1 318 patients were included in 9 cohorts. Meta-analysis showed that compared with traditional thoracoscopic surgery, 鍗曞瓟鑳歌厰闀滄墜鏈不鐤楄偤鐧岃兏鑵斿紩娴佹椂闂存洿鐭璠MD= 0.70,95%CI( 1.38, 0.02),P=0.04],浣忛櫌鏃堕棿鏇寸煭[MD= 0.52,95%CI( 0.91, 0.14),P=0.007],鏈腑鍑鸿閲忔洿灏慬MD= 18.49,95%CI( 33.61, 3.37),P=0.02],鏈悗绗，
本文编号：2242123
[Abstract]:Objective to evaluate the clinical effect of single-hole thoracoscopy and traditional multi-hole thoracoscopy in the treatment of lung cancer. Methods the database of Pub Med,The Cochrane Library (2016 (3rd issue) was searched by computer. The randomized controlled trial and cohort study of single hole thoracoscopy and traditional porous thoracoscopic surgery for lung cancer were collected. The retrieval time was established until April 2016. Two researchers independently sifted the literature, extracted the data and evaluated the bias risk in the study, and then used Rev Man 5.3 software to carry out Meta analysis. Results A total of 1 318 patients were included in 9 cohorts. Meta-analysis showed that compared with traditional thoracoscopic surgery, 鍗曞瓟鑳歌厰闀滄墜鏈不鐤楄偤鐧岃兏鑵斿紩娴佹椂闂存洿鐭璠MD= 0.70,95%CI( 1.38, 0.02),P=0.04],浣忛櫌鏃堕棿鏇寸煭[MD= 0.52,95%CI( 0.91, 0.14),P=0.007],鏈腑鍑鸿閲忔洿灏慬MD= 18.49,95%CI( 33.61, 3.37),P=0.02],鏈悗绗，
本文编号：2242123
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