CD73在恶性肿瘤中作用机制的研究进展
发布时间：2018-09-19 14:50
【摘要】：腺苷信号通路是恶性肿瘤的发生发展重要调节因素。CD73的酶活性可以将一磷酸腺苷水解为腺苷,是产生腺苷的关键分子。最新研究发现,CD73在多种癌症细胞系和患者肿瘤组织中呈过表达现象。CD73的表达情况和癌症患者的临床病理特征及预后相关。证实CD73是恶性肿瘤发展的一种关键因子。以CD73为靶点的靶向治疗恶性肿瘤的动物实验已经取得了可喜的效果,并使得抗CD73靶向治疗可能成为一种颇具前景的肿瘤治疗方法。本文就CD73在各种恶性肿瘤中的表达情况及其对患者预后的影响,CD73与肿瘤生长、肿瘤转移等的关系,CD73在肿瘤微环境中免疫抑制作用以及抗CD73治疗肿瘤等方面进行综述。
[Abstract]:Adenosine signaling pathway is an important regulatory factor for the development of malignant tumors. The enzyme activity of CD73 can hydrolyze adenosine monophosphate into adenosine, which is the key molecule of adenosine production. Recent studies have found that the overexpression of CD73 in various cancer cell lines and tumor tissues is related to the clinicopathological features and prognosis of cancer patients. It is confirmed that CD73 is a key factor in the development of malignant tumor. The animal experiment of CD73 targeted treatment of malignant tumor has achieved gratifying results and made anti-CD73 targeted therapy a promising tumor treatment method. This article reviews the expression of CD73 in various malignant tumors and its influence on prognosis. The relationship between CD73 and tumor growth, tumor metastasis and immunosuppressive effect of CD73 in tumor microenvironment, as well as antitumor therapy with CD73, are reviewed.
【作者单位】： 上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科;
【分类号】：R73-3
本文编号：2250447
[Abstract]:Adenosine signaling pathway is an important regulatory factor for the development of malignant tumors. The enzyme activity of CD73 can hydrolyze adenosine monophosphate into adenosine, which is the key molecule of adenosine production. Recent studies have found that the overexpression of CD73 in various cancer cell lines and tumor tissues is related to the clinicopathological features and prognosis of cancer patients. It is confirmed that CD73 is a key factor in the development of malignant tumor. The animal experiment of CD73 targeted treatment of malignant tumor has achieved gratifying results and made anti-CD73 targeted therapy a promising tumor treatment method. This article reviews the expression of CD73 in various malignant tumors and its influence on prognosis. The relationship between CD73 and tumor growth, tumor metastasis and immunosuppressive effect of CD73 in tumor microenvironment, as well as antitumor therapy with CD73, are reviewed.
【作者单位】： 上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科;
【分类号】：R73-3
【相似文献】
相关期刊论文 前3条
1 石源源;刘丽;高程凤;李清;;CD73在肿瘤中的研究进展[J];中国当代医药;2010年22期
2 封全灵;王红丽;张毅;史惠蓉;张斌;;宫颈癌患者外周血中髓源抑制细胞比例变化及CD73的表达[J];郑州大学学报(医学版);2014年04期
3 ;[J];;年期
相关博士学位论文 前1条
1 于忆;肾癌肿瘤干细胞相关抗原CD73和DLL4表达情况研究重组PEAs-pVAX1-DLL4转染移植瘤鼠的实验研究[D];兰州大学;2015年
相关硕士学位论文 前1条
1 陆小霞;HIF-1α、CD73和FOXP3在胃癌组织中的表达及其临床意义[D];南京大学;2013年
，本文编号：2250447
本文链接：https://www.wllwen.com/yixuelunwen/zlx/2250447.html
