化疗方案对食管癌放疗的增效作用研究进展
发布时间：2018-10-04 20:22
【摘要】：晚期食管癌患者接受单纯放疗后的生存率不高,治疗失败的主要原因是局部未控和远处转移。化疗可起到提高肿瘤局部控制率、预防及治疗肿瘤远处转移的作用,其有效率为35%~55%。放化疗联合应用于食管癌治疗,既能增强肿瘤组织对放疗的敏感性,又能提高化疗药物的治疗效果;二者相互协同,共同阻滞肿瘤进展及转移,最终延长患者的生存时间。因此,在同步放化疗的基础上优化各种化疗方案,成为了近年来局部晚期食管癌研究的热点之一。本文即对不同化疗方案在食管癌临床应用中的放疗增效作用进行综述。
[Abstract]:The survival rate of patients with advanced esophageal cancer after radiotherapy alone was not high. The main causes of failure were local uncontrolled and distant metastasis. Chemotherapy can improve the local control rate of tumor, prevent and treat distant metastasis of tumor, its effective rate is 3555. The combination of radiotherapy and chemotherapy can not only enhance the sensitivity of tumor tissue to radiotherapy, but also improve the therapeutic effect of chemotherapeutic drugs. Therefore, the optimization of various chemotherapy protocols based on concurrent radiotherapy and chemotherapy has become one of the hotspots in the study of locally advanced esophageal cancer in recent years. This article reviews the synergistic effects of different chemotherapy regimens in the clinical application of esophageal cancer.
【作者单位】： 济南大学山东省医学科学院医学与生命科学学院;山东大学附属山东省肿瘤医院放疗科;
【分类号】：R735.1
[Abstract]:The survival rate of patients with advanced esophageal cancer after radiotherapy alone was not high. The main causes of failure were local uncontrolled and distant metastasis. Chemotherapy can improve the local control rate of tumor, prevent and treat distant metastasis of tumor, its effective rate is 3555. The combination of radiotherapy and chemotherapy can not only enhance the sensitivity of tumor tissue to radiotherapy, but also improve the therapeutic effect of chemotherapeutic drugs. Therefore, the optimization of various chemotherapy protocols based on concurrent radiotherapy and chemotherapy has become one of the hotspots in the study of locally advanced esophageal cancer in recent years. This article reviews the synergistic effects of different chemotherapy regimens in the clinical application of esophageal cancer.
【作者单位】： 济南大学山东省医学科学院医学与生命科学学院;山东大学附属山东省肿瘤医院放疗科;
【分类号】：R735.1
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