基线高敏C-反应蛋白水平与男性吸烟人群肺癌发病风险队列研究

发布时间：2018-10-05 08:41

【摘要】：目的探讨高敏C-反应蛋白(high sensitivity C-reactive protein,hs CRP)与男性吸烟人群肺癌发病的关联性。方法以参加2006年7月开滦集团体检的男性吸烟人群建立队列,收集基线调查资料和hs CRP实验室检测结果。通过每2年1次的体检和每年1次的目标人群健康状况相关信息数据库检索,收集肺癌发病和死亡等结局信息。采用多因素Cox比例风险回归模型分析男性吸烟人群基线hs CRP水平与肺癌发病风险,调整变量包括年龄、吸烟程度、饮酒、体质指数和糖尿病史情况。结果至2014年12月31日,纳入队列38 099人,随访期内共收集新发肺癌333例。hsCRP1 mg/L组、hsCRP 1~3 mg/L组和hsCRP3 mg/L组中新发肺癌8年累积发病率分别为727/10万、995/10万和1 344/10万,组间差异具有统计学意义(X~2=23.79,P0.001)。调整年龄、吸烟程度、饮酒、体质指数和糖尿病史后,hsCRP 1~3 mg/L组和hsCRP3 mg/L组患者肺癌发病风险分别是hsCRP1 mg/L组的1.37倍和1.69倍,差异均有统计学意义(95%CI:1.06~1.77,P=0.017;95%CI:1.29~2.23,P0.001)。结论基线hs CRP水平升高增加了男性吸烟人群肺癌发病风险。
[Abstract]:Objective to investigate the association between Gao Min C-reactive protein (high sensitivity C-reactive protein,hs CRP) and lung cancer in male smokers. Methods A cohort of male smokers who took part in the physical examination of Kailuan Group in July 2006 was used to collect the baseline survey data and the results of hs CRP laboratory tests. The outcome information of lung cancer was collected by searching the relevant information database of the health status of the target population once every 2 years and once a year. Multivariate Cox proportional risk regression model was used to analyze baseline hs CRP levels and lung cancer risk in male smokers. The adjusted variables included age, smoking degree, alcohol consumption, body mass index and diabetes history. Results as of December 31, 2014, 38,099 patients were enrolled in the cohort. During the follow-up period, a total of 333 cases of newly diagnosed lung cancer were collected. The cumulative incidence of newly diagnosed lung cancer in the mg/L group and hsCRP3 mg/L group was 727 / 100 000, 995 / 100 000 and 13.44% / 100 million, respectively. The difference between groups was statistically significant (XG 223.79 P 0.001). The risk of lung cancer was 1.37 times and 1.69 times higher in mg/L group and hsCRP3 mg/L group than in hsCRP1 mg/L group, respectively (95CI: 1.06C 1.77p 0.017%, 95 CI: 1.292.23P0.001). The risk of lung cancer in patients with adjusted age, smoking, alcohol consumption, BMI and diabetes history were 1.37 and 1.69 times higher than those in hsCRP1 mg/L group respectively (95 CI: 1.06, 1.77%, 0.017%, 95 CI: 1.292.23, P0.001). Conclusion the increase of baseline hs CRP level increases the risk of lung cancer in male smokers.
【作者单位】：开滦总医院肿瘤科;国家癌症中心中国医学科学院北京协和医学院肿瘤医院全国肿瘤防治研究办公室;开滦总医院心内科;
【基金】：国家自然科学基金(81673265;81373079) 公益性行业科研专项(201402003) 北京协和医学院“协和青年基金”(3332016131;33320140168) 北京市科技新星(XX2012067)
【分类号】：R734.2

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