中国女性乳腺癌患者术后复发影响因素meta分析

发布时间：2018-10-09 13:31

【摘要】：目的探讨中国女性乳腺癌患者术后复发的影响因素,为改善乳腺癌患者预后提供参考依据。方法检索中国学术文献总库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、Web Of Science数据库、Pubmed数据库、Science Direct数据库和BIOSIS数据库,并辅以手工检索和文献追溯法收集2000年1月1日—2013年12月31日公开发表的关于中国女性乳腺癌患者术后复发影响因素的相关文献;应用Rev Man 5.2和SAS 9.2软件对纳入的文献进行meta分析。结果最终纳入25篇中文文献,共累计女性乳腺癌患者16 471例,其中术后复发患者1 048例,复发率为6.36%;meta分析结果显示,肿瘤直径2 cm(OR=2.89,95%CI=1.76~4.74)、肿瘤分期Ⅱ期(OR=3.79,95%CI=3.08~4.66)、原发灶T分期T2期(OR=3.78,95%CI=2.47~5.78)、有淋巴结转移(OR=2.68,95%CI=1.67~4.31)、淋巴结转移数目3个(OR=3.17,95%CI=2.49~4.03)和人表皮生长因子2阳性(OR=2.85,95%CI=2.21~3.67)为中国女性乳腺癌患者术后复发的危险因素,雌激素受体/孕激素受体阳性(OR=0.47,95%CI=0.38~0.59)和术后放疗(OR=0.21,95%CI=0.12~0.36)为中国女性乳腺癌患者术后复发的保护因素;敏感性分析和发表偏倚评估结果显示,纳入的文献不存在发表偏倚,结果较为可靠。结论肿瘤直径、肿瘤分期、淋巴结转移状态、淋巴结转移数目、原发灶T分期、人表皮生长因子2状态、雌激素受体/孕激素受体状态和术后放疗情况是中国女性乳腺癌患者术后复发的主要影响因素。
[Abstract]:Objective to investigate the influencing factors of postoperative recurrence of female breast cancer patients in China, and to provide reference for improving the prognosis of breast cancer patients. Methods Chinese academic literature database (CNKI), Wanfang database, Chinese biomedical literature database (CBM) web Of Science database, (CNKI), Direct database and BIOSIS database were searched. The related literatures on the factors influencing the recurrence of female breast cancer patients in China from January 1, 2000 to December 31, 2013 were collected by manual retrieval and literature tracing. Rev Man 5.2 and SAS 9.2 software were used to analyze the literature by meta. Results A total of 16 471 cases of female breast cancer were included in 25 Chinese literatures, including 1 048 cases of postoperative recurrence. The recurrence rate was 6. 36%. Tumor diameter 2 cm (OR=2.89,95%CI=1.76~4.74), tumor stage 鈪，

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