射频消融术联合化疗治疗进展期非小细胞肺癌远期疗效的回顾性研究
发布时间：2018-10-10 07:53
【摘要】：背景与目的肺癌射频消融术(radiofrequency ablation,RFA)联合化疗对于晚期非小细胞肺癌(nonsmall cell lung cancer,NSCLC)近期疗效的改善具有一定的意义,但其是否可以改善晚期NSCLC患者的远期生存仍然存在争议。本研究回顾性分析了射频消融术联合化疗治疗与单纯化疗对于晚期NSCLC患者的远期疗效的差异。方法选择2012年9月-2015年12月在首都医科大学宣武医院胸外科进行肺癌射频消融术并进行化疗的Ⅲb期与Ⅳ期NSCLC患者77例作为实验组,选择同期只进行化疗未进行射频消融术的Ⅲb期与Ⅳ期NSCLC患者56例作为对照组。对两组患者进行电话随访,询问患者目前的生存情况与死亡时间。运用R3.4.1软件进行统计分析,使用"survival"程序包,用卡方检验比较两组数据基线水平,运用Cox比例风险模型处理混杂偏倚,并使用协变量均值取代法绘制经过校对的生存曲线。结果两组基线齐,实验组的1年生存率为70.74%,2年生存率为39.31%,中位生存期为22.1个月;对照组的1年生存率为54.54%,2年生存率为19.49%,中位生存期为18.1个月。组间差异有统计学意义(P0.05)。结论对于Ⅲb期-Ⅳ期NSCLC患者,肺癌射频消融术联合化疗治疗可以显著提高患者的2年生存率。
[Abstract]:Background & objective radiofrequency ablation (radiofrequency ablation,RFA) combined with chemotherapy has certain significance in improving the short-term curative effect of advanced non-small cell lung cancer (nonsmall cell lung cancer,NSCLC), but whether it can improve the long-term survival of patients with advanced NSCLC is still controversial. This study retrospectively analyzed the long-term effects of radiofrequency ablation combined with chemotherapy and chemotherapy alone in patients with advanced NSCLC. Methods from September 2012 to December 2015, 77 patients with stage 鈪，
本文编号：2261234
[Abstract]:Background & objective radiofrequency ablation (radiofrequency ablation,RFA) combined with chemotherapy has certain significance in improving the short-term curative effect of advanced non-small cell lung cancer (nonsmall cell lung cancer,NSCLC), but whether it can improve the long-term survival of patients with advanced NSCLC is still controversial. This study retrospectively analyzed the long-term effects of radiofrequency ablation combined with chemotherapy and chemotherapy alone in patients with advanced NSCLC. Methods from September 2012 to December 2015, 77 patients with stage 鈪，
本文编号：2261234
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