肿瘤床出血的非典型垂体腺瘤组织中Ki-67与CD34的表达

发布时间：2018-10-16 12:19

【摘要】：目的:探讨CD34在发生肿瘤床出血(TBB)的非典型垂体腺瘤(APA)组织中的表达及与TBB的关系。方法:收集194例手术治疗的垂体腺瘤患者资料,采用免疫组化法检测Ki-67和CD34的表达情况,研究17例APA的临床资料、MRI表现和免疫组化特点,分析APA术中发生TBB与CD34表达水平之间的关系。结果:17例APA均为巨大腺瘤;14例APA术中发生少到中等量的出血,肿瘤全部切除;2例出现严重的TBB,行肿瘤次全切术。MRI表现多为T1WI等信号或T2WI等-高信号,增强扫描明显强化。17例APA的Ki-67 LI范围为3.2%~12.0%;CD34在发生TBB的16例APA与无TBB垂体腺瘤组织中的表达量分别为(26.8±7.7)和(10.6±5.3),差异有统计学意义(P=0.025)。结论:CD34阳性表达和肿瘤富血供的MRI表现特点相结合有助于了解APA发生TBB的机制,判断和预测APA的预后。
[Abstract]:Objective: to investigate the expression of CD34 in (APA) of atypical pituitary adenomas with (TBB) and its relationship with TBB. Methods: the data of 194 patients with pituitary adenoma treated by operation were collected and the expression of Ki-67 and CD34 were detected by immunohistochemical method. The clinical data, MRI manifestations and immunohistochemical features of 17 cases of APA were studied. To analyze the relationship between TBB and CD34 expression during APA. Results: all of the 17 cases of APA were giant adenoma, 14 cases of APA suffered from moderate to moderate bleeding, and 2 cases had severe subtotal resection of TBB,. The results of MRI showed that the signal intensity of T1WI or T2WI was high. The expression of CD34 in 17 cases of APA was (26.8 卤7.7) and (10.6 卤5.3), respectively. The expression of CD34 in 16 cases with TBB and without TBB was (26.8 卤7.7) and (10.6 卤5.3), respectively, and the difference was statistically significant (P0.025). Conclusion: the combination of the positive expression of CD34 and the MRI features of the tumor rich in blood supply is helpful to understand the mechanism of TBB in APA and to judge and predict the prognosis of APA.
【作者单位】：河南中医药大学第一附属医院磁共振科;郑州大学第一附属医院神经外科;
【基金】：国家自然科学基金资助项目U1204807 河南省中医药科学研究专项课题2015ZY02014
【分类号】：R736.4

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