荧光联合纳米炭在乳腺癌前哨淋巴结活检中的应用

发布时间：2018-10-17 11:55

【摘要】：目的探讨乳腺癌前哨淋巴结活检(SLNB)中吲哚菁绿(ICG)联合纳米炭悬浊液的应用价值。方法将110例腋窝淋巴结阴性的早期乳腺癌患者,随机分成两组,分别采用注射用ICG联合纳米炭悬浊液(联合组,57例)和单用纳米炭悬浊液(纳米炭组,53例)为示踪剂行SLNB。SLNB后随即行腋窝淋巴结清扫。结果联合组中55例可见荧光所示淋巴管道,荧光显像率96.49%(55/57),前哨淋巴结检出率98.25%(56/57),准确率96.43%(54/56),假阴性率6.67%(2/30),灵敏度93.33%(28/30);纳米炭组前哨淋巴结检出率94.34%(50/53),准确率96.00%(48/50),假阴性率8.33%(2/24),灵敏度91.67%(22/24)。联合组共检出前哨淋巴结309枚,纳米炭组共检出前哨淋巴结218枚,两组前哨淋巴结平均检出枚数比较差异有统计学意义(P0.05);而两组检出率、准确率、假阴性率和灵敏度这4个评价指标比较,差异均无统计学意义。结论 ICG与纳米炭悬浊液联合应用相比单用纳米炭悬浊液可提高前哨淋巴结检出数量,减少漏诊概率。
[Abstract]:Objective to evaluate the value of indocyanine green (ICG) combined with carbon nanoparticles suspension in sentinel lymph node biopsy (SLNB) of breast cancer. Methods 110 patients with early breast cancer with negative axillary lymph nodes were randomly divided into two groups. The axillary lymph nodes were dissected by ICG combined with nano-carbon suspension (combined group, 57 cases) and only by nano-carbon suspension (nano-carbon group, 53 cases) respectively. The axillary lymph nodes were dissected immediately after SLNB.SLNB. Results in the combined group, the lymphatic ducts were detected in 55 cases, the detection rate of the sentinel lymph nodes was 98.25% (56 / 57), the accuracy rate was 96.43% (54 / 56), the false negative rate was 6.67% (2 / 30), the sensitivity was 93.33% (28 / 30), the detection rate of sentinel lymph nodes was 94.34% (50 / 53), the accuracy rate was 96.00% (48 / 50), the false negative rate was 8.33% (2 / 24), the sensitivity was 91.67% (22 / 24) in the combined group, the accuracy rate was 96.00% (48 / 50), the false negative rate was 8.33% (2 / 24), the sensitivity was 91.67% (22 / 24). A total of 309 sentinel lymph nodes were detected in the combined group and 218 in the carbon nano-group. The average number of sentinel lymph nodes detected in the two groups was significantly different (P0.05); There was no significant difference in false negative rate and sensitivity. Conclusion ICG combined with nano-carbon suspension can increase the number of sentinel lymph node detection and reduce the probability of missed diagnosis.
【作者单位】：安徽医科大学第一附属医院乳腺外科;中国科学技术大学工程科学学院;
【基金】：安徽省自然科学基金(编号:11040606M180)
【分类号】：R737.9

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