胃肠道神经内分泌肿瘤临床特征及预后分析
发布时间：2018-10-17 12:48
【摘要】：目的胃肠道神经内分泌肿瘤(gastrointestinal neuroendocrine neoplasm,GI-NEN)较常见,近年来其发病率明显上升。本研究回顾性分析GI-NEN患者的临床特征,并探讨影响其预后的相关因素。方法分析2007-02-01-2013-02-28四川省人民医院收治的109例GI-NEN患者的临床特征及随访资料,采用Cox回归模型探讨影响患者预后的相关因素。结果 109例GI-NEN患者中,胃部神经内分泌肿瘤49例(44.95%),肠部神经内分泌肿瘤60例(55.05%)。淋巴结转移患者38例(34.86%),远处转移患者18例(16.51%)。患者临床表现均无功能性,主要表现为消化道非特异性症状或肿瘤局部占位症状。随访中位生存期为30个月,1、3、5年生存率分别为77.98%(85/109)、54.13%(59/109)和40.37%(44/109)。单因素分析显示,不同肿瘤大小、病理分类、病理分级和是否伴有远处转移的GI-NEN患者之间生存率差异有统计学意义,P0.05。多元Cox回归分析显示,病理分级G2(HR=1.54,95%CI:1.04~2.29)和G3(HR=3.67,95%CI:1.85~7.31)(均相较于病理分级G1),以及伴远处转移(HR=2.02,95%CI:1.02~3.98)是GI-NEN患者预后的危险因素。结论 GI-NEN患者临床表现无特异性,伴远处转移和病理分级较晚是GI-NEN患者的预后独立危险因素。
[Abstract]:Objective Gastrointestinal neuroendocrine neoplasms (gastrointestinal neuroendocrine neoplasm,GI-NEN) are more common and their incidence has increased significantly in recent years. This study retrospectively analyzed the clinical features of patients with GI-NEN, and explored the prognostic factors. Methods the clinical features and follow-up data of 109 patients with GI-NEN admitted to Sichuan Provincial people's Hospital from January to January, 2007 were analyzed. The factors related to the prognosis of the patients were investigated by Cox regression model. Results there were 49 cases (44.95%) of gastric neuroendocrine tumors and 60 cases (55.05%) of intestinal neuroendocrine tumors. There were 38 cases (34.86%) with lymph node metastasis and 18 cases (16.51%) with distant metastasis. The clinical manifestations of the patients were nonfunctional, mainly characterized by non-specific gastrointestinal symptoms or local tumor occupying symptoms. The median survival time was 30 months, and the survival rates were 77.98% (85 / 109), 54.13% (59 / 109) and 40.37% (44 / 109), respectively. Univariate analysis showed that there were significant differences in survival rate among GI-NEN patients with different tumor size, pathological classification, pathological grade and distant metastasis (P0.05). Multiple Cox regression analysis showed that pathological grade G2 (HR=1.54,95%CI:1.04~2.29), G3 (HR=3.67,95%CI:1.85~7.31) (compared with pathological grade G1) and distant metastasis (HR=2.02,95%CI:1.02~3.98) were risk factors for prognosis of GI-NEN patients. Conclusion there is no specificity in clinical manifestations of GI-NEN patients. Distant metastasis and late pathological grading are independent prognostic risk factors in GI-NEN patients.
【作者单位】： 四川省医学科学院·四川省人民医院胃肠外科;
【分类号】：R735
，
本文编号：2276711
[Abstract]:Objective Gastrointestinal neuroendocrine neoplasms (gastrointestinal neuroendocrine neoplasm,GI-NEN) are more common and their incidence has increased significantly in recent years. This study retrospectively analyzed the clinical features of patients with GI-NEN, and explored the prognostic factors. Methods the clinical features and follow-up data of 109 patients with GI-NEN admitted to Sichuan Provincial people's Hospital from January to January, 2007 were analyzed. The factors related to the prognosis of the patients were investigated by Cox regression model. Results there were 49 cases (44.95%) of gastric neuroendocrine tumors and 60 cases (55.05%) of intestinal neuroendocrine tumors. There were 38 cases (34.86%) with lymph node metastasis and 18 cases (16.51%) with distant metastasis. The clinical manifestations of the patients were nonfunctional, mainly characterized by non-specific gastrointestinal symptoms or local tumor occupying symptoms. The median survival time was 30 months, and the survival rates were 77.98% (85 / 109), 54.13% (59 / 109) and 40.37% (44 / 109), respectively. Univariate analysis showed that there were significant differences in survival rate among GI-NEN patients with different tumor size, pathological classification, pathological grade and distant metastasis (P0.05). Multiple Cox regression analysis showed that pathological grade G2 (HR=1.54,95%CI:1.04~2.29), G3 (HR=3.67,95%CI:1.85~7.31) (compared with pathological grade G1) and distant metastasis (HR=2.02,95%CI:1.02~3.98) were risk factors for prognosis of GI-NEN patients. Conclusion there is no specificity in clinical manifestations of GI-NEN patients. Distant metastasis and late pathological grading are independent prognostic risk factors in GI-NEN patients.
【作者单位】： 四川省医学科学院·四川省人民医院胃肠外科;
【分类号】：R735
，
本文编号：2276711
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