前列腺癌的诊疗进展
发布时间：2018-10-17 14:59
【摘要】：前列腺癌发病率高,起病隐匿,潜伏期长,出现症状时往往已伴有局部浸润或远处转移,早期诊断和治疗能有效降低前列腺癌患者的死亡率。在早期诊断方面,直肠指检和前列腺特异性抗原提高了前列腺癌诊断的敏感性,但其低特异性也造成了大量的过度医疗;在治疗方面,前列腺癌根治术辅以内分泌治疗对前列腺癌有一定的疗效,但绝大多数患者最终进展为去势抵抗性前列腺癌,从而严重影响患者的生存期。近年来,前列腺癌肿瘤标志物和影像学技术成为人们研究的热点,并取得了重大进展,显著提高前列腺癌早期诊断的准确率,为肿瘤预后评估提供了重要依据。同时前列腺癌新型药物的研制亦取得了前所未有的进展,多种靶向治疗药物及免疫治疗药物逐步问世。本文就前列腺癌最新诊断和治疗进展作一综述。
[Abstract]:The incidence of prostate cancer is high, the onset is hidden, the incubation period is long, and the symptoms are often accompanied by local infiltration or distant metastasis. Early diagnosis and treatment can effectively reduce the mortality of patients with prostate cancer. In early diagnosis, rectal finger examination and prostate specific antigen increased the sensitivity of prostate cancer diagnosis, but its low specificity also resulted in a large amount of overtreatment; in treatment, Radical prostatectomy combined with endocrine therapy has a certain curative effect on prostate cancer, but the majority of patients eventually progress to castration resistant prostate cancer, which seriously affects the survival time of the patients. In recent years, tumor markers and imaging techniques of prostate cancer have become the focus of research, and great progress has been made. The accuracy of early diagnosis of prostate cancer has been significantly improved, which provides an important basis for the evaluation of tumor prognosis. At the same time, the development of new prostatic cancer drugs has made unprecedented progress. This article reviews the latest diagnosis and treatment of prostate cancer.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.25
本文编号：2277051
[Abstract]:The incidence of prostate cancer is high, the onset is hidden, the incubation period is long, and the symptoms are often accompanied by local infiltration or distant metastasis. Early diagnosis and treatment can effectively reduce the mortality of patients with prostate cancer. In early diagnosis, rectal finger examination and prostate specific antigen increased the sensitivity of prostate cancer diagnosis, but its low specificity also resulted in a large amount of overtreatment; in treatment, Radical prostatectomy combined with endocrine therapy has a certain curative effect on prostate cancer, but the majority of patients eventually progress to castration resistant prostate cancer, which seriously affects the survival time of the patients. In recent years, tumor markers and imaging techniques of prostate cancer have become the focus of research, and great progress has been made. The accuracy of early diagnosis of prostate cancer has been significantly improved, which provides an important basis for the evaluation of tumor prognosis. At the same time, the development of new prostatic cancer drugs has made unprecedented progress. This article reviews the latest diagnosis and treatment of prostate cancer.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.25
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相关期刊论文 前4条
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