康复新联合小牛血清去蛋白治疗直肠癌术后放疗致急性放射性直肠炎的临床疗效及其对血小板功能的影响

发布时间：2018-10-20 10:55

【摘要】：目的探究康复新联合小牛血清去蛋白治疗直肠癌术后放疗致急性放射性直肠炎的临床疗效,并观察其对血小板功能的影响。方法选取2011年3月—2014年10月郑州大学第二附属医院收治的直肠癌术后放疗致急性放射性直肠炎患者64例,按照随机数字表法分为对照组和研究组,每组32例。研究组患者给予康复新联合小牛血清去蛋白治疗,对照组仅给予康复新保留灌肠治疗。比较两组患者治疗前后急性放射性直肠炎分级、肠道疼痛分级、KPS评分、平均血小板体积(MPV)及临床疗效。结果治疗前两组患者急性放射性直肠炎分级、肠道疼痛分级比较,差异无统计学意义(P0.05);治疗后研究组患者急性放射性直肠炎分级、肠道疼痛分级优于对照组(P0.05);两组患者治疗后急性放射性直肠炎分级、肠道疼痛分级均优于治疗前(P0.05)。治疗前后两组患者KPS评分、MPV比较,差异无统计学意义(P0.05);研究组治疗后MPV大于治疗前(P0.05)。研究组临床疗效优于对照组(P0.05)。结论康复新联合小牛血清去蛋白治疗直肠癌术后放疗致急性放射性直肠炎的临床疗效较好,能有效改善血小板功能。
[Abstract]:Objective to investigate the clinical effect of Kangangxin combined with calf serum deproteinization in the treatment of acute radiation-induced proctitis induced by postoperative radiotherapy for rectal cancer and to observe its effect on platelet function. Methods from March 2011 to October 2014, 64 patients with acute radiation proctitis caused by postoperative radiotherapy for rectal cancer were selected and divided into control group (n = 32) and study group (n = 32). The patients in the study group were treated with Kangangxin combined with calf serum deproteinization, while the control group were treated only with Kangangxin retention enema. The acute radiation proctitis grade, intestinal pain grade, KPS score, mean platelet volume (MPV) and clinical efficacy were compared between the two groups before and after treatment. Results there was no significant difference in acute radiation proctitis and intestinal pain between the two groups before treatment (P0.05). The grade of intestinal pain was better than that of the control group (P0.05); the grade of acute radiation proctitis and the grade of intestinal pain were better than those before treatment in both groups (P0.05). There was no significant difference in KPS score and MPV between the two groups before and after treatment (P0.05); the MPV after treatment in study group was higher than that before treatment (P0.05). The clinical effect of the study group was better than that of the control group (P0.05). Conclusion Kangkangxin combined with calf serum deproteinization is effective in the treatment of acute radiation-induced proctitis after postoperative radiotherapy for rectal cancer and can effectively improve platelet function.
【作者单位】：郑州大学第二附属医院中药学部;
【基金】：郑州市科技局“常州四药临床药学科研基金”(CZSYJJ14014)
【分类号】：R735.37

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