参芪二仙颗粒治疗肺癌患者化疗相关性疲乏的临床疗效观察
发布时间：2018-10-20 12:17
【摘要】：研究目的:研制简便、实用的中成药参芪二仙颗粒,通过随机对照的临床研究验证其疗效,发挥中医药治疗肺癌化疗相关性疲乏的优势。研究方法:在中医理论指导下,结合科室临床使用经验,将科室协定处方参芪二仙汤按照标准的工艺加工研制为参芪二仙颗粒。纳入以肺癌化疗后相关性疲乏为主要症状的患者76例,采用随机的方法分为治疗组(化疗及基础治疗+参芪二仙颗粒)和对照组(单纯化疗及基础治疗),观察参芪二仙颗粒对患者化疗后疲乏程度、中医证候积分、生存质量等的影响。采用SPSS17.0进行统计分析,其中计数资料按卡方检验、计量资料按t检验分析,检验水准为P0.05。研究结果:1、治疗前两组患者疲乏程度量表得分、中医症候积分、生存质量得分差异无统计学意义(P0.05)。经治疗后治疗组疲乏量表总分及各维度得分均降低,除认知维度外,情感维度、躯体维度疲乏差异具有统计学意义(P0.05)。中医证后积分下降具有统计学意义(P0.05)。生存质量评分有所提高,除社会状况维度外,其余维度差异均具有统计学意义(P0.05)。2、治疗组白细胞、淋巴细胞、血小板及血红蛋白水平有所改善,其中白细胞、淋巴细胞和血红蛋白具有统计学意义(P0.05)。对照组出现骨髓抑制32例,治疗组出现骨髓抑制21例,差异具有统计学意义(P0.05)。3、对照组化疗过程中出现胃肠道反应15例,治疗组共见12例,组间差异无统计学意义(P0.05)。研究结论:参芪二仙颗粒对肺癌患者化疗相关性疲乏的改善具有确切疗效,可以提高患者生存质量,具有临床推广应用的价值。
[Abstract]:Objective: to develop a simple and practical Chinese patent medicine Shenqi Erxian granule. The therapeutic effect of Shenqi Erxian granule was verified by randomized controlled clinical study to give full play to the advantage of traditional Chinese medicine in the treatment of lung cancer chemotherapy-related fatigue. Methods: under the guidance of the theory of traditional Chinese medicine and the clinical experience of the department, Shenqi Erxian decoction was prepared into Shenqi Erxian granule according to the standard technology. A total of 76 patients with lung cancer associated fatigue after chemotherapy were included. The patients were randomly divided into treatment group (chemotherapy and basic treatment) and control group (simple chemotherapy and basic treatment). The fatigue degree of Shenqi Erxian granule after chemotherapy and TCM syndromes score were observed. The influence of quality of life, etc. The statistical analysis was carried out by SPSS17.0, in which the counting data were checked by chi-square test, and the measured data were analyzed by t-test. The test level was P0.05. Results: 1, before the treatment of the two groups of patients fatigue scale score, TCM symptom score, quality of life score no significant difference (P0.05). After treatment the total score of fatigue scale and the scores of each dimension were decreased except cognitive dimension emotional dimension and somatic dimension fatigue difference was statistically significant (P0.05). After TCM syndromes score decreased statistically significant (P0.05). The scores of quality of life were improved, except the social status dimension, the differences of other dimensions were statistically significant (P0.05). 2. The levels of white blood cells, lymphocytes, platelets and hemoglobin were improved in the treatment group, in which white blood cells, blood platelets and hemoglobin were improved. Lymphocyte and hemoglobin had statistical significance (P0.05). There were 32 cases of bone marrow suppression in the control group and 21 cases in the treatment group, the difference was statistically significant (P0.05). In the control group, gastrointestinal reaction occurred in 15 cases during chemotherapy, and 12 cases in the treatment group. There was no significant difference between the two groups (P0.05). Conclusion: Shenqi Erxian granule has definite curative effect on the improvement of chemotherapy-related fatigue in lung cancer patients, it can improve the quality of life of patients, and has the value of clinical popularization and application.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2
，
本文编号：2283158
[Abstract]:Objective: to develop a simple and practical Chinese patent medicine Shenqi Erxian granule. The therapeutic effect of Shenqi Erxian granule was verified by randomized controlled clinical study to give full play to the advantage of traditional Chinese medicine in the treatment of lung cancer chemotherapy-related fatigue. Methods: under the guidance of the theory of traditional Chinese medicine and the clinical experience of the department, Shenqi Erxian decoction was prepared into Shenqi Erxian granule according to the standard technology. A total of 76 patients with lung cancer associated fatigue after chemotherapy were included. The patients were randomly divided into treatment group (chemotherapy and basic treatment) and control group (simple chemotherapy and basic treatment). The fatigue degree of Shenqi Erxian granule after chemotherapy and TCM syndromes score were observed. The influence of quality of life, etc. The statistical analysis was carried out by SPSS17.0, in which the counting data were checked by chi-square test, and the measured data were analyzed by t-test. The test level was P0.05. Results: 1, before the treatment of the two groups of patients fatigue scale score, TCM symptom score, quality of life score no significant difference (P0.05). After treatment the total score of fatigue scale and the scores of each dimension were decreased except cognitive dimension emotional dimension and somatic dimension fatigue difference was statistically significant (P0.05). After TCM syndromes score decreased statistically significant (P0.05). The scores of quality of life were improved, except the social status dimension, the differences of other dimensions were statistically significant (P0.05). 2. The levels of white blood cells, lymphocytes, platelets and hemoglobin were improved in the treatment group, in which white blood cells, blood platelets and hemoglobin were improved. Lymphocyte and hemoglobin had statistical significance (P0.05). There were 32 cases of bone marrow suppression in the control group and 21 cases in the treatment group, the difference was statistically significant (P0.05). In the control group, gastrointestinal reaction occurred in 15 cases during chemotherapy, and 12 cases in the treatment group. There was no significant difference between the two groups (P0.05). Conclusion: Shenqi Erxian granule has definite curative effect on the improvement of chemotherapy-related fatigue in lung cancer patients, it can improve the quality of life of patients, and has the value of clinical popularization and application.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2
，
本文编号：2283158
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