RAGE与RECK在涎腺多形性腺瘤复发及恶变中的表达及意义

发布时间：2018-10-21 15:10

【摘要】：目的:检测RAGE、RECK在涎腺多形性腺瘤(pleomorphic adenoma,PA)初发、复发和恶变中的表达情况及临床意义。方法:免疫组化法分别检测正常13例,PA初发36例、复发8例,恶变10例涎腺组织RAGE及RECK的表达情况,分析其表达的差异性,并探讨其相关性。结果:RAGE在正常、初发、复发及恶变标本中阳性表达率分别为:15.40%、41.70%、62.50%、90.00%,呈逐渐升高的趋势,并且在阳性率和表达强度比较发现,正常、初发组均明显低于复发及恶变组,差异具有统计学意义(P0.05)。RECK在正常、初发、复发及恶变标本中阳性表达率分别为:76.90%、55.60%、37.50%、20.00%,呈逐渐降低的趋势,并且在阳性率和表达强度比较发现,正常、初发组均明显高于复发及恶变组,差异具有统计学意义(P0.05)。RAGE和RECK在各组中的表达呈负相关性(r=-0.512,P0.05)。结论:本研究结果可能进一步阐述多形性腺瘤复发及恶变的发病机制,为辅助预测患者预后及为患者的综合治疗提供参考。
[Abstract]:Objective: to detect the expression of RAGE,RECK in salivary pleomorphic adenoma (pleomorphic adenoma,PA) and its clinical significance. Methods: the expression of RAGE and RECK in salivary gland of 13 normal cases, 36 cases of PA, 8 cases of recurrence and 10 cases of malignant change were detected by immunohistochemical method. Results: the positive expression rates of RAGE in normal, primary, recurrent and malignant specimens were 15.40 and 41.70, 62.50 and 90.000.The positive rate and expression intensity of RAGE were higher than those of recurrent and malignant change. The difference was statistically significant (P0.05) the positive expression rates of). RECK in normal, primary, recurrent and malignant specimens were 76.901 / 55.60 and 37.50 / 20.00, respectively, and the positive rate and expression intensity were significantly higher in the normal, primary and malignant groups than in the recurrent and malignant groups. The difference was statistically significant (P0.05) the expression of). RAGE and RECK in each group showed a negative correlation (r-0.512 P 0.05). Conclusion: the results of this study may further elucidate the pathogenesis of recurrence and malignancy of pleomorphic adenoma, and provide a reference for the prognosis prediction and comprehensive treatment of pleomorphic adenoma.
【作者单位】：新疆医科大学第一附属医院颌面肿瘤外科;
【基金】：新疆维吾尔自治区自然科学基金(编号:2016D01C313)
【分类号】：R739.87

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