肝癌非手术治疗“治疗抵抗”的研究进展
发布时间：2018-10-29 14:06
【摘要】：肝癌具有高度恶性和预后不良的特点。肝移植和肝切除只适用于少部分肿瘤局限的患者。由于起病隐匿,绝大部分肝癌患者被诊断时已为中晚期或者合并严重肝硬化,临床治疗以非手术为主,如经导管肝动脉化疗栓塞(transarterial chemoembolization,TACE)、局部消融、放疗、靶向药物等;治疗方式虽然多样,但肝癌复发转移的发生率很高。非手术治疗效果不理想,可能存在肝癌对每种治疗方式有一定的"治疗抵抗"。积极改进现有的治疗方案,对延长患者的生存期、提高患者的生活质量具有重要的意义。
[Abstract]:Liver cancer is characterized by high malignancy and poor prognosis. Liver transplantation and hepatectomy are only suitable for a small number of patients with localized tumors. Because of the occult onset, most patients with liver cancer have been diagnosed as advanced or severe cirrhosis. The main clinical treatment is non-operative, such as transcatheter hepatic artery chemoembolization (transarterial chemoembolization,TACE), local ablation, radiotherapy, targeted drugs and so on. Although various treatment methods, but the incidence of recurrence and metastasis of liver cancer is very high. The effect of non-operative treatment is not ideal, and there may be some resistance to treatment of liver cancer. It is of great significance to improve the current treatment plan for prolonging the survival time and improving the quality of life of the patients.
【作者单位】： 复旦大学附属中山医院肝癌研究所;
【分类号】：R735.7
[Abstract]:Liver cancer is characterized by high malignancy and poor prognosis. Liver transplantation and hepatectomy are only suitable for a small number of patients with localized tumors. Because of the occult onset, most patients with liver cancer have been diagnosed as advanced or severe cirrhosis. The main clinical treatment is non-operative, such as transcatheter hepatic artery chemoembolization (transarterial chemoembolization,TACE), local ablation, radiotherapy, targeted drugs and so on. Although various treatment methods, but the incidence of recurrence and metastasis of liver cancer is very high. The effect of non-operative treatment is not ideal, and there may be some resistance to treatment of liver cancer. It is of great significance to improve the current treatment plan for prolonging the survival time and improving the quality of life of the patients.
【作者单位】： 复旦大学附属中山医院肝癌研究所;
【分类号】：R735.7
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