CD147表达与结直肠癌临床病理因素及预后研究
发布时间：2018-11-01 18:09
【摘要】：目的本研究旨在探讨CD147与结直肠癌患者术后临床病理因素及预后的相关性,说明CD147是否能够成为指导临床有效指标。方法回顾性分析蚌埠医学院附属泰兴医院普通外科2012年1月至2013年12月收治入院手术的124例结直肠癌患者的临床资料,采用免疫组化的方法分析CD147表达与患者临床病理资料、术后应激及恢复情况以及预后之间关系。结果根据CD147表达情况将结果分为阴性和阳性,阳性中分为弱阳性、中度阳性、强阳性。免疫组化结果显示CD147表达阴性46例,表达阳性78例,其中弱阳性35例,中度阳性26例,强阳性17例,在结直肠癌患者中CD147阳性率62.9%,高于正常组织中的23.4%,差异有统计学意义(P0.01)。CD147在结直肠癌中表达与患者性别、年龄、肿瘤位置、肿瘤大小、分化程度间差异均无统计学意义(P0.05),而与肿瘤的淋巴结转移、远处转移、浸润深度、TMN分期之间差异有统计学意义(P0.05)。单因素方差分析结果显示CD147表达与术后白细胞计数、中性粒细胞计数、血浆白蛋白、通气时间、住院天数之间差异无统计学意义(P0.05)。Kaplan-Meier分析显示CD147表达与患者的生存率成负相关,患者肿瘤细胞中CD147表达越高生存期越短,CD147表达与患者术后短期生存率差异有显著统计学意义(P0.01)。结论结直肠癌组织中CD147表达增高,与结直肠癌的转移有关,表达越高的患者术后预后越差,可以成为结直肠癌预后的监测指标。
[Abstract]:Objective to investigate the correlation between CD147 and postoperative clinicopathological factors and prognosis in colorectal cancer patients, and to see whether CD147 can be used as an effective index for clinical application. Methods the clinical data of 124 patients with colorectal cancer treated in general surgery department of Taixing Hospital affiliated to Bengbu Medical College from January 2012 to December 2013 were analyzed retrospectively. The expression of CD147 and the clinicopathological data of the patients were analyzed by immunohistochemical method. The relationship between stress, recovery and prognosis after operation. Results according to the expression of CD147, the results were classified as negative and positive. The positive was divided into weak positive, moderate positive and strong positive. Immunohistochemical results showed that CD147 was negative in 46 cases and positive in 78 cases, including weak positive 35 cases, moderate positive 26 cases and strong positive 17 cases. The positive rate of CD147 in colorectal cancer was 62.9%, which was higher than that in normal tissues (23.4%). There was no significant difference between CD147 expression and sex, age, tumor location, tumor size and differentiation degree in colorectal cancer (P0.05), but there was no significant difference between CD147 expression and lymph node metastasis. There were significant differences in distant metastasis, depth of invasion and TMN stage (P0.05). Univariate analysis of variance showed that CD147 expression was associated with postoperative leukocyte count, neutrophil count, plasma albumin, and ventilation time. Kaplan-Meier analysis showed that the expression of CD147 was negatively correlated with the survival rate of the patients, and the higher the expression of CD147 was, the shorter the survival time was. The expression of CD147 was significantly different from the short-term survival rate (P 0. 01). Conclusion the increased expression of CD147 in colorectal carcinoma is related to the metastasis of colorectal cancer. The higher the expression of CD147 is, the worse the postoperative prognosis is, and the higher the expression is, the better the prognosis of colorectal cancer is.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R735.34
本文编号：2304692
[Abstract]:Objective to investigate the correlation between CD147 and postoperative clinicopathological factors and prognosis in colorectal cancer patients, and to see whether CD147 can be used as an effective index for clinical application. Methods the clinical data of 124 patients with colorectal cancer treated in general surgery department of Taixing Hospital affiliated to Bengbu Medical College from January 2012 to December 2013 were analyzed retrospectively. The expression of CD147 and the clinicopathological data of the patients were analyzed by immunohistochemical method. The relationship between stress, recovery and prognosis after operation. Results according to the expression of CD147, the results were classified as negative and positive. The positive was divided into weak positive, moderate positive and strong positive. Immunohistochemical results showed that CD147 was negative in 46 cases and positive in 78 cases, including weak positive 35 cases, moderate positive 26 cases and strong positive 17 cases. The positive rate of CD147 in colorectal cancer was 62.9%, which was higher than that in normal tissues (23.4%). There was no significant difference between CD147 expression and sex, age, tumor location, tumor size and differentiation degree in colorectal cancer (P0.05), but there was no significant difference between CD147 expression and lymph node metastasis. There were significant differences in distant metastasis, depth of invasion and TMN stage (P0.05). Univariate analysis of variance showed that CD147 expression was associated with postoperative leukocyte count, neutrophil count, plasma albumin, and ventilation time. Kaplan-Meier analysis showed that the expression of CD147 was negatively correlated with the survival rate of the patients, and the higher the expression of CD147 was, the shorter the survival time was. The expression of CD147 was significantly different from the short-term survival rate (P 0. 01). Conclusion the increased expression of CD147 in colorectal carcinoma is related to the metastasis of colorectal cancer. The higher the expression of CD147 is, the worse the postoperative prognosis is, and the higher the expression is, the better the prognosis of colorectal cancer is.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R735.34
【参考文献】
相关期刊论文 前3条
1 曹敏;卢宁;;CD_(147)与MMP-2和MMP-9在乳腺癌中的研究进展[J];医学综述;2015年07期
2 陈娟;卢宁;黄建国;王勇强;赵晓伟;谢伟;;CD147和MMP-9在结直肠癌组织中的表达及临床意义[J];临床肿瘤学杂志;2013年11期
3 封兰兰;朱少君;张阳;李艳红;巩丽;兰淼;韩秀娟;姚丽;张伟;;HAb18G/CD147在多种恶性肿瘤中的表达及其临床意义[J];细胞与分子免疫学杂志;2013年09期
，本文编号：2304692
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