胃蛋白酶原、癌胚抗原、黏蛋白类癌胚抗原联合检测对胃癌的诊断及鉴别诊断效能

发布时间：2018-11-03 09:49

【摘要】：目的观察胃蛋白酶原(PG)、癌胚抗原(CEA)、黏蛋白类癌胚抗原(CA72-4)联合检测对胃癌的诊断和鉴别诊断效能。方法胃癌患者45例(A组)、胃溃疡患者66例(B组)、萎缩性胃炎患者47例(C组)、慢性非萎缩性胃炎患者40例(D组),采用ELISA法检测血清PGⅠ、PGⅡ,计算胃蛋白酶原比值(PGR,PGⅠ/PGⅡ);化学发光法检测血清CEA、CA72-4。分析PGⅠ、PGⅡ、CEA、CA72-4单独及联合检测诊断胃癌的敏感度和特异度。结果与D组比较,A组PGⅠ、PGR降低和CEA、CA72-4升高,B组PGⅠ、PGⅡ升高,C组PGⅠ、PGR降低和PGⅡ升高,P均0.05;与C组比较,A组PGⅡ降低和CEA、CA72-4升高,P均0.05。单独检测诊断胃癌的敏感度和特异度以PGR为最高,分别为62.5%、75.7%。联合检测诊断胃癌的敏感度和特异度以PGⅠ、PGR、CEA、CA72-4联合为最高,分别为85.6和92.5%。结论 PG、CEA、CA72-4联合检测有助于胃癌的诊断及鉴别诊断,可作为胃癌筛查的指标。
[Abstract]:Objective to investigate the diagnostic and differential diagnostic efficacy of pepsinogen (PG), carcinoembryonic antigen (CEA),) mucin carcinoembryonic antigen (CA72-4) in gastric cancer. Methods 45 patients with gastric cancer (group A), 66 patients with gastric ulcer (group B), 47 patients with atrophic gastritis (group C) and 40 patients with chronic non-atrophic gastritis (group D) were examined by ELISA method. The pepsinogen ratio (PGR,PG 鈪，

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