原发性肝癌患者肝动脉化疗栓塞术治疗前、后血浆D-二聚体变化的临床意义

发布时间：2018-11-04 15:02

【摘要】：目的探讨血浆D-二聚体(D-D)水平变化在原发性肝癌(PHC)患者TACE治疗中的临床意义。方法收集69例原发性肝癌患者的临床资料,根据m RECIST标准将患者分为病情控制组(CR+PR+SD)及病情进展组(PD),TACE治疗前、后血浆D-D水平的差异性采用秩和检验,D-D判断TACE疗效的效能采用ROC曲线分析。结果病情控制组TACE治疗前、后血浆D-D分别为124.00(88.00,212.00)、190.00(75.00,273.00)μg/L,差异无统计学意义(P0.05);病情进展组TACE治疗前、后血浆D-D分别为261.50(138.25,559.50)、554.50(398.25,1 080.00)μg/L,治疗前D-D水平高于病情控制组(P0.05),治疗后D-D水平进一步升高,差异有统计学意义(P0.05)。根据ROC曲线分析,TACE治疗前、后血浆D-D判断术后疗效的曲线下面积分别为0.737、0.907,两者分别取界值181.5、339.0μg/L时,判断术后疗效的灵敏度和特异度分别为71.4%、70.7%及85.7%、87.8%。结论血浆D-D水平变化对PHC患者病情评估及TACE疗效有一定评估作用,血浆D-D升高,意味着患者病情较重,TACE疗效差。
[Abstract]:Objective to investigate the clinical significance of plasma D-dimer (D-D) level in TACE treatment of patients with primary liver cancer (PHC). Methods the clinical data of 69 patients with primary liver cancer were collected. According to m RECIST criteria, the patients were divided into two groups: (CR PR SD) group and (PD), TACE group. The difference of plasma D-D level was measured by rank sum test before and after (PD), TACE treatment. D-D was used to evaluate the efficacy of TACE by ROC curve analysis. Results before and after TACE treatment, plasma D-D was 124.00 (88.00212.00) and 190.00 (75.00273.00) 渭 g / L in the disease control group (P0.05). Before and after TACE treatment, the plasma D-D levels were 261.50 (138.25559.50), 554.50 (398.251.080.00) 渭 g / L, respectively. The D-D level before treatment was higher than that in the disease control group (P0.05). D-D level increased further after treatment, the difference was statistically significant (P0.05). According to the ROC curve analysis, the area under the plasma D-D curve before and after TACE treatment was 0.7370.907, and the boundary value was 181.5339.0 渭 g / L, respectively. The sensitivity and specificity were 70.7% and 87.8%, respectively. Conclusion the change of plasma D-D level has a certain effect on the evaluation of PHC patients' condition and the curative effect of TACE. The increase of plasma D-D level means that the patients' condition is serious and the curative effect of TACE is poor.
【作者单位】：中国医科大学附属盛京医院放射科;
【分类号】：R735.7

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