微环境调控肿瘤代谢的研究

发布时间：2018-11-07 11:15

【摘要】：20世纪20年代,奥托·瓦博格首次发现肿瘤细胞在正常氧的情况下优先利用糖酵解的现象.近一个世纪以来,细胞代谢在肿瘤发生发展中的作用引起了广泛的关注.其基本机制是肿瘤细胞在营养匮乏的环境中通过劫持、重塑不同的细胞代谢途径,包括合成和分解途径,从而为其生存和增殖提供生物大分子原料;而这些代谢途径改变和代谢物的变化通过转录、表观、翻译和翻译后修饰等不同机制来调控细胞的生命活动,从而在肿瘤发生发展中起着至关重要的作用.因此,代谢异常是肿瘤的十大特征之一.近年来,随着对癌基因和抑癌基因的突变以及各类生长因子和下游信号通路的深入研究,特别是近十年对肿瘤细胞所处的微环境在肿瘤发生发展中的关键作用不断阐明,人们逐步认识到肿瘤细胞和其所处微环境的相互作用对肿瘤代谢的重塑产生重要的影响,因此揭示微环境对肿瘤细胞代谢的调控机制,将为肿瘤的诊断和治疗提供新的靶点和合理化治疗方案,从而提高肿瘤病人的生存率及其生活质量.
[Abstract]:In the 1920s, Otto Wabog first discovered that tumor cells preferentially use glycolysis under normal oxygen conditions. In the past century, the role of cell metabolism in tumorigenesis and development has attracted wide attention. The basic mechanism of tumor cells is to remodel different metabolic pathways, including synthesis and decomposition, through hijacking in the environment of poor nutrition, so as to provide biological macromolecular raw materials for their survival and proliferation. These changes in metabolic pathways and metabolites play an important role in the development of cancer through different mechanisms such as transcriptional, apparent, translational and post-translational modification. Therefore, abnormal metabolism is one of the ten characteristics of tumor. In recent years, with the in-depth study of mutations of oncogenes and tumor suppressor genes and various growth factors and downstream signaling pathways, especially the key role of microenvironment in tumor cells in tumorigenesis and development in the last decade, It has been gradually recognized that the interaction between tumor cells and their microenvironment has an important effect on the remodeling of tumor metabolism, thus revealing the mechanism of microenvironment regulating the metabolism of tumor cells. It will provide a new target and rational treatment for tumor diagnosis and treatment, so as to improve the survival rate and quality of life of tumor patients.
【作者单位】：复旦大学肿瘤医院肿瘤研究所和生物医学研究院肿瘤代谢实验室;
【基金】：国家重大科学研究计划(2015CB910400) 国家自然科学基金(81430057)资助项目~~
【分类号】：R730.2

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