乳腺癌干细胞近年的主要研究进展

发布时间：2018-11-07 11:34

【摘要】：背景:随着对乳腺癌发生、发展机制的不断深入研究,乳腺癌干细胞日益受到重视。目的:对乳腺癌干细胞的特征、调控乳腺癌干细胞的相关信号通路以及乳腺癌干细胞与上皮间质转化、乳腺癌转移、肿瘤微环境、治疗抵抗等方面的主要研究进展做一综述。方法:由第一作者以"Breast cancer,Stem cells,Signaling pathway,Epithelial mesenchymal transition,Tumor microenvironment"为关键词,检索PubM ed等数据库从2001至2017年的相关文献,排除与文章研究目的无关及重复性的文章,纳入符合标准的60篇文献进行综述。结果与结论:肿瘤干细胞学说的提出解释了肿瘤转移和复发的根本原因,为肿瘤治疗提供一个新的研究思路,随着对乳腺癌干细胞的致病分子机制、特性和相关分子调控机制的深入研究,明确了乳腺癌干细胞在乳腺癌发生、发展中所扮演的角色,对靶向乳腺癌干细胞的肿瘤治疗方法的研究具有重要指导意义。
[Abstract]:Background: with the development of breast cancer, breast cancer stem cells have been paid more and more attention. Objective: to review the characteristics of breast cancer stem cells, the regulation of the signal pathway of breast cancer stem cells, the transformation between breast cancer stem cells and epithelial mesenchymal cells, breast cancer metastasis, tumor microenvironment, therapeutic resistance and so on. Methods: by using "Breast cancer,Stem cells,Signaling pathway,Epithelial mesenchymal transition,Tumor microenvironment" as the key word, the first author searched the relevant literatures of PubM ed and other databases from 2001 to 2017, and excluded articles that were not related to the purpose of the article and which were repetitive. A total of 60 articles that meet the criteria were reviewed. Results & conclusion: the theory of tumor stem cell explained the root cause of tumor metastasis and recurrence, and provided a new research idea for tumor therapy, along with the pathogenesis of breast cancer stem cells. The further study on the characteristics and molecular regulation mechanism of breast cancer has clarified the role of breast cancer stem cells in the occurrence and development of breast cancer and has important guiding significance for the study of tumor treatment methods targeting breast cancer stem cells.
【作者单位】：中国药科大学中药学院;香港中文大学中医中药研究所及植物化学与西部植物资源持续利用国家重点实验室伙伴实验室;
【基金】：中国药科大学高层次人才引进项目(1050020013,3010020056,3010020057) 国家自然科学基金项目(31470428)~~
【分类号】：R737.9

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