农村和城市食管鳞癌患者生存影响因素对比分析
发布时间：2018-11-07 12:07
【摘要】：目的:探讨农村和城市地区差异对食管鳞癌患者生存影响。方法:36 723例食管鳞癌患者临床诊疗、病理和随访信息全部取自郑州大学第一附属医院河南省食管癌重点开放实验室50万例食管癌和贲门癌生物样本数据库(1973年至2015年)。农村患者33 625例(91.6%),其中男性20 906例,平均诊断年龄(58.98±8.71)岁;女性12 719例,平均诊断年龄(59.59±8.53)岁;城市患者3 098例(8.4%),其中男性2 089例,平均诊断年龄(60.84±9.10)岁;女性1 009例,平均诊断年龄(62.46±9.14)岁。所有患者均行食管癌根治术治疗,并记录完整病理TNM分期。采用χ~2检验、Kaplan-Meier,Log-rank和多因素Cox风险比例回归模型方法分析各组间差异及生存影响因素。结果:Kaplan-Meier和Log-rank总体分析显示:农村食管癌患者整体生存明显优于城市患者(χ~2=12.971,P0.001);年龄、性别和TNM分期多因素分层分析显示:农村年龄≥50岁男性和女性Ⅱa、Ⅱb(中期)的患者生存明显优于城市患者(男性:χ~2=16.188,P0.001;女性:χ~2=5.019,P=0.025);但是,0、Ⅰa、Ⅰb(早期)和Ⅲa、Ⅲc、Ⅳ期(晚期)农村和城市患者生存差异无统计学意义(P0.05)。Cox比例风险回归模型分析显示:影响农村和城市患者生存的独立危险因素均为年龄、性别和TNM分期;而农村和城市患者综合分析显示:男性、诊断年龄≥50岁、城市和TNM分期是食管鳞癌患者预后差的独立危险因素。结论:农村地区食管癌患者整体生存优于城市患者;男性、诊断年龄≥50岁、城市和TNM分期是食管鳞癌患者预后差的独立危险因素。
[Abstract]:Objective: to investigate the influence of the difference between rural and urban areas on the survival of esophageal squamous cell carcinoma patients. Methods: the clinical diagnosis and treatment of 36 723 patients with esophageal squamous cell carcinoma were studied. All the pathological and follow-up information were obtained from the database of biological samples of 500000 cases of esophageal carcinoma and cardia carcinoma in Henan Provincial key Open Laboratory of esophageal Cancer, the first affiliated Hospital of Zhengzhou University (1973-2015). There were 33,625 (91.6%) patients in rural areas, 20 906 males (mean diagnostic age 58.98 卤8.71), 12719 females (59.59 卤8.53) years old. There were 3 098 cases (8.4%) in urban area, of which 2089 cases were male, the average diagnostic age was (60.84 卤9.10) years old, the average diagnostic age was (62.46 卤9.14) years old in female 1 009 cases. All patients were treated with radical resection of esophageal carcinoma and complete pathological TNM staging was recorded. 蠂 ~ 2 test, Kaplan-Meier,Log-rank and multivariate Cox risk ratio regression model were used to analyze the differences and survival factors among the groups. Results: Kaplan-Meier and Log-rank analysis showed that the overall survival of rural patients with esophageal cancer was significantly better than that of urban patients (蠂 ~ 2 ~ (12.971) P 0.001). The multivariate stratification analysis of age, sex and TNM stage showed that the patients with rural age 鈮，
本文编号：2316321
[Abstract]:Objective: to investigate the influence of the difference between rural and urban areas on the survival of esophageal squamous cell carcinoma patients. Methods: the clinical diagnosis and treatment of 36 723 patients with esophageal squamous cell carcinoma were studied. All the pathological and follow-up information were obtained from the database of biological samples of 500000 cases of esophageal carcinoma and cardia carcinoma in Henan Provincial key Open Laboratory of esophageal Cancer, the first affiliated Hospital of Zhengzhou University (1973-2015). There were 33,625 (91.6%) patients in rural areas, 20 906 males (mean diagnostic age 58.98 卤8.71), 12719 females (59.59 卤8.53) years old. There were 3 098 cases (8.4%) in urban area, of which 2089 cases were male, the average diagnostic age was (60.84 卤9.10) years old, the average diagnostic age was (62.46 卤9.14) years old in female 1 009 cases. All patients were treated with radical resection of esophageal carcinoma and complete pathological TNM staging was recorded. 蠂 ~ 2 test, Kaplan-Meier,Log-rank and multivariate Cox risk ratio regression model were used to analyze the differences and survival factors among the groups. Results: Kaplan-Meier and Log-rank analysis showed that the overall survival of rural patients with esophageal cancer was significantly better than that of urban patients (蠂 ~ 2 ~ (12.971) P 0.001). The multivariate stratification analysis of age, sex and TNM stage showed that the patients with rural age 鈮，
本文编号：2316321
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