胃癌合并Hp-L感染患者MIF和MMP-9表达变化及其与血清炎症因子的关系
发布时间：2018-11-07 13:12
【摘要】：目的研究胃癌合并幽门螺杆菌L型(Hp-L)感染患者促黑激素释放抑制因子(MIF)、基质金属蛋白酶9(MMP-9)表达变化及其与血清炎症因子的关系。方法用免疫组织化学法检测50例胃癌患者(观察组)和50例健康志愿者(对照组)胃组织中MIF与MMP-9的表达,用酶联免疫吸附法(ELISA)检测白细胞介素(IL)-1β、IL-6在两组受试者血清中的水平,并用革兰染色镜检两组受试者胃组织中的Hp感染情况。结果观察组中Hp-L感染阳性者有38例,感染率为76.00%,明显高于对照组12例(24.00%),差异有统计学意义(P0.01)。观察组胃组织中MIF、MMP-9的表达强于对照组,同时合并Hp-L感染阳性者组织中MIF、MMP-9的表达强于Hp-L感染阴性者,差异有统计学意义(P0.01)。观察组患者血清IL-1β、IL-6的浓度高于对照组,合并Hp-L感染阳性者IL-1β、IL-6的浓度高于Hp-L感染阴性者,差异有统计学意义(P0.01)。结论 MIF、MMP-9、IL-1β、IL-6与胃癌的发生、发展有关,其机制也与Hp-L感染有关。
[Abstract]:Objective to study the expression of melanocyte releasing inhibitor (MIF), matrix metalloproteinase 9 (MMP-9) in patients with gastric cancer complicated with Helicobacter pylori L type (Hp-L) infection and its relationship with serum inflammatory factors. Methods the expressions of MIF and MMP-9 in gastric tissues of 50 patients with gastric cancer (observation group) and 50 healthy volunteers (control group) were detected by immunohistochemical method, and interleukin (IL) 1 尾 (IL 1 尾) was detected by (ELISA) with enzyme linked immunosorbent assay (Elisa). The level of IL-6 in the serum of the two groups and the Hp infection in gastric tissue of the two groups were examined by Gram staining. Results in the observation group, 38 cases were positive for Hp-L infection, and the infection rate was 76.00%, which was significantly higher than that in the control group (24.00%). The difference was statistically significant (P0.01). The expression of MIF,MMP-9 in gastric tissues of the observation group was stronger than that in the control group, and the expression of MIF,MMP-9 in the patients with positive Hp-L infection was stronger than that in the patients with negative Hp-L infection (P0.01). The serum levels of IL-1 尾 and IL-6 in the observation group were higher than those in the control group, and the concentrations of IL-1 尾 and IL-6 in the patients with positive Hp-L infection were higher than those in the patients with Hp-L infection negative (P0.01). Conclusion MIF,MMP-9,IL-1 尾 and IL-6 are related to the occurrence and development of gastric cancer, and its mechanism is also related to Hp-L infection.
【作者单位】： 乐山职业技术学院病理教研室;四川省成都市第六人民医院病理科;
【分类号】：R735.2
本文编号：2316477
[Abstract]:Objective to study the expression of melanocyte releasing inhibitor (MIF), matrix metalloproteinase 9 (MMP-9) in patients with gastric cancer complicated with Helicobacter pylori L type (Hp-L) infection and its relationship with serum inflammatory factors. Methods the expressions of MIF and MMP-9 in gastric tissues of 50 patients with gastric cancer (observation group) and 50 healthy volunteers (control group) were detected by immunohistochemical method, and interleukin (IL) 1 尾 (IL 1 尾) was detected by (ELISA) with enzyme linked immunosorbent assay (Elisa). The level of IL-6 in the serum of the two groups and the Hp infection in gastric tissue of the two groups were examined by Gram staining. Results in the observation group, 38 cases were positive for Hp-L infection, and the infection rate was 76.00%, which was significantly higher than that in the control group (24.00%). The difference was statistically significant (P0.01). The expression of MIF,MMP-9 in gastric tissues of the observation group was stronger than that in the control group, and the expression of MIF,MMP-9 in the patients with positive Hp-L infection was stronger than that in the patients with negative Hp-L infection (P0.01). The serum levels of IL-1 尾 and IL-6 in the observation group were higher than those in the control group, and the concentrations of IL-1 尾 and IL-6 in the patients with positive Hp-L infection were higher than those in the patients with Hp-L infection negative (P0.01). Conclusion MIF,MMP-9,IL-1 尾 and IL-6 are related to the occurrence and development of gastric cancer, and its mechanism is also related to Hp-L infection.
【作者单位】： 乐山职业技术学院病理教研室;四川省成都市第六人民医院病理科;
【分类号】：R735.2
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1 杨土英;赵亚刚;;Hp-L型、Livin与胃癌关系的研究进展[J];实用医学杂志;2012年13期
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