复方苦参注射液联合含奥沙利铂化疗方案治疗大肠癌疗效与安全性的系统评价
发布时间：2018-11-08 20:35
【摘要】：目的:系统评价复方苦参注射液联合含奥沙利铂化疗方案治疗大肠癌的疗效和安全性,为临床提供循证参考。方法:计算机检索相关期刊论文、万方数据库、中国生物医学文献数据库、中文科技期刊数据库、PubMed、Cochrane图书馆,收集复方苦参注射液联合含奥沙利铂化疗方案(试验组)对比常规化疗方案(对照组)治疗大肠癌的随机对照试验(RCT),提取资料并依据改良的Jadad量表进行质量评价后,采用RevMan 5.3统计软件进行Meta分析。结果:最终纳入33项RCT,合计2 801例患者。Meta分析结果显示,试验组患者近期有效率[RR=1.34,95%CI(1.24,1.46),P0.001]、功能状态(KPS)评分改善率[RR=1.87,95%CI(1.65,2.14),P0.001]、CD4~+/CD8~+[WMD=0.49,95%CI(0.26,0.72),P0.001]、CD4~+水平[WMD=10.34,95%CI(7.00,13.69),P0.001]、CD3~+水平[WMD=5.85,95%CI(4.07,7.62),P0.001]、自然杀伤细胞水平[WMD=3.52,95%CI(1.76,5.27),P0.001]、白细胞介素(IL)-2水平[WMD=12.96,95%CI(10.39,15.53),P0.001]显著高于对照组,CD8~+水平[WMD=-5.89,95%CI(-11.39,-0.40),P=0.04]、IL-10水平[WMD=-21.04,95%CI(-29.15,-12.94),P0.001]、恶心呕吐发生率[RR=0.72,95%CI(0.67,0.78),P0.001]、白细胞减少发生率[RR=0.52,95%CI(0.45,0.61),P0.001]、肝功能异常发生率[RR=0.63,95%CI(0.53,0.74),P0.001]、周围神经毒性发生率[RR=0.77,95%CI(0.64,0.92),P=0.005]显著低于对照组,差异均有统计学意义。结论:复方苦参注射液联合含奥沙利铂化疗方案治疗大肠癌疗效优于单纯化疗,可以提高患者生存质量,改善免疫功能,降低化疗引起的不良反应。
[Abstract]:Objective: to evaluate the efficacy and safety of compound Sophora flavescens injection combined with oxaliplatin chemotherapy in the treatment of colorectal cancer. Methods: the full text database of Chinese periodicals, Wanfang database, Chinese biomedical literature database, Chinese sci-tech journal database, PubMed,Cochrane library were searched by computer. To collect the data of (RCT), extraction from the randomized controlled trial of compound Sophora flavescens injection combined with oxaliplatin chemotherapy regimen (trial group) and compare with conventional chemotherapy regimen (control group) and evaluate the quality according to the modified Jadad scale. Meta analysis was carried out with RevMan 5.3 statistical software. Results: 33 items of RCT, were included in the total of 2 801 patients. The results of Meta analysis showed that the short-term effective rate of patients in the trial group [RR=1.34,95%CI (1.24 卤1.46), P0.001]. The improvement rate of (KPS) score of functional state [RR=1.87,95%CI (1.65m2.14), P0.001], CD4~ / CD8~ [WMD=0.49,95%CI (0.260.72), P0.001], CD4~ level [WMD=10.34,95%CI (7.000.69), P0.001]; The levels of CD3~ [WMD=5.85,95%CI (4.07, 7.62), P0.001], natural killer cells [WMD=3.52,95%CI (1.76m5.27), P0.001], interleukin (IL) 2 (WMD=12.96,95%CI (10.39) 15.53), The levels of CD8~ [WMD=-5.89,95%CI (-11.39) -0.40], P0. 04, IL-10 [WMD=-21.04,95%CI (-29.15-12.94), P0. 001] were significantly higher than those in the control group. The incidence of nausea and vomiting [RR=0.72,95%CI (0.67 ~ 0.78), P0.001], leukopenia [RR=0.52,95%CI (0.450.61), P0.001], the incidence of abnormal liver function [RR=0.63,95%CI (0.53 卤0.74)], The incidence of peripheral neurotoxicity [RR=0.77,95%CI (0.64 卤0.92), P _ (0.005)] was significantly lower than that of the control group (P 0.001), and the difference was statistically significant. Conclusion: the therapeutic effect of compound Sophora flavescens injection combined with oxaliplatin chemotherapy in the treatment of colorectal cancer is better than that of chemotherapy alone, which can improve the quality of life, improve the immune function and reduce the adverse reactions caused by chemotherapy.
【作者单位】： 广州中医药大学第四临床医学院/深圳市中医院;广州中医药大学第二临床医学院;
【分类号】：R735.34
[Abstract]:Objective: to evaluate the efficacy and safety of compound Sophora flavescens injection combined with oxaliplatin chemotherapy in the treatment of colorectal cancer. Methods: the full text database of Chinese periodicals, Wanfang database, Chinese biomedical literature database, Chinese sci-tech journal database, PubMed,Cochrane library were searched by computer. To collect the data of (RCT), extraction from the randomized controlled trial of compound Sophora flavescens injection combined with oxaliplatin chemotherapy regimen (trial group) and compare with conventional chemotherapy regimen (control group) and evaluate the quality according to the modified Jadad scale. Meta analysis was carried out with RevMan 5.3 statistical software. Results: 33 items of RCT, were included in the total of 2 801 patients. The results of Meta analysis showed that the short-term effective rate of patients in the trial group [RR=1.34,95%CI (1.24 卤1.46), P0.001]. The improvement rate of (KPS) score of functional state [RR=1.87,95%CI (1.65m2.14), P0.001], CD4~ / CD8~ [WMD=0.49,95%CI (0.260.72), P0.001], CD4~ level [WMD=10.34,95%CI (7.000.69), P0.001]; The levels of CD3~ [WMD=5.85,95%CI (4.07, 7.62), P0.001], natural killer cells [WMD=3.52,95%CI (1.76m5.27), P0.001], interleukin (IL) 2 (WMD=12.96,95%CI (10.39) 15.53), The levels of CD8~ [WMD=-5.89,95%CI (-11.39) -0.40], P0. 04, IL-10 [WMD=-21.04,95%CI (-29.15-12.94), P0. 001] were significantly higher than those in the control group. The incidence of nausea and vomiting [RR=0.72,95%CI (0.67 ~ 0.78), P0.001], leukopenia [RR=0.52,95%CI (0.450.61), P0.001], the incidence of abnormal liver function [RR=0.63,95%CI (0.53 卤0.74)], The incidence of peripheral neurotoxicity [RR=0.77,95%CI (0.64 卤0.92), P _ (0.005)] was significantly lower than that of the control group (P 0.001), and the difference was statistically significant. Conclusion: the therapeutic effect of compound Sophora flavescens injection combined with oxaliplatin chemotherapy in the treatment of colorectal cancer is better than that of chemotherapy alone, which can improve the quality of life, improve the immune function and reduce the adverse reactions caused by chemotherapy.
【作者单位】： 广州中医药大学第四临床医学院/深圳市中医院;广州中医药大学第二临床医学院;
【分类号】：R735.34
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