顺铂腹腔热灌注化疗对胃癌患者术后免疫功能和预后的影响

发布时间：2018-11-13 10:06

【摘要】：目的探讨顺铂腹腔热灌注化疗(HIPC)对胃癌患者术后免疫功能和预后的影响。方法胃癌手术患者90例按随机数字表法分为对照组和观察组,每组45例,两组均接受胃癌根治术和静脉化疗方案,观察组在此基础上给予HIPC。治疗完成后,随访调查患者生存质量、化疗疗效、化疗毒副作用发生情况和T细胞亚群改变情况。结果观察组治疗后CD3~+、CD4~+和CD4~+/CD8~+比值均显著升高(P0.05),而CD8~+显著低于治疗前(P0.05),对照组治疗前后差异无统计学意义(P0.05);观察组治疗后生存质量和疗效显著优于对照组(P0.05);两组化疗毒副作用发生率差异无统计学意义(P0.05)。结论 HIPC较传统化疗疗效更佳,可以提高患者生存质量,改善患者免疫功能,但其毒副作用暂时未发现,有待延长随访时间和扩大样本量做进一步研究。
[Abstract]:Objective to investigate the effect of cisplatin intraperitoneal hyperthermic infusion chemotherapy (HIPC) on postoperative immune function and prognosis in patients with gastric cancer. Methods 90 patients with gastric cancer were divided into control group (n = 45) and observation group (n = 45) according to random digital table method. Both groups received radical gastrectomy and intravenous chemotherapy. The observation group was given HIPC. on this basis. After the treatment, the quality of life, the curative effect of chemotherapy, the side effects of chemotherapy and the changes of T cell subsets were investigated. Results after treatment, CD3~, CD4~ and CD4~ / CD8~ ratio increased significantly in the observation group (P0.05), but CD8~ was significantly lower than that before treatment (P0.05), while there was no significant difference before and after treatment in the control group (P0.05). The quality of life and curative effect in the observation group were significantly better than those in the control group (P0.05); there was no significant difference in the incidence of side effects of chemotherapy between the two groups (P0.05). Conclusion HIPC is more effective than traditional chemotherapy, it can improve the quality of life and improve the immune function of patients, but its side effects have not been found for the time being, so it needs to be further studied by prolonging the follow-up time and expanding the sample size.
【作者单位】：南阳市中心医院肿瘤内科一病区;
【分类号】：R735.2

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