绝经前后中国女性BMI与乳腺癌发病关系的剂量-反应meta分析

发布时间：2018-11-19 09:03

【摘要】：目的探讨不同绝经状态下中国女性BMI与乳腺癌发病的关系。方法计算机检索Pub Med、EMBASE、万方数据库、维普数据库、相关期刊论文(CNKI),收集国内外2000年1月至2017年2月公开发表的关于中国女性不同体质指数(BMI)分组与乳腺癌发病关系的研究文献。应用Stata12.0进行Meta分析,在总体效应关系存在的基础上,进行线性和非线性模型拟合,若未发现剂量反应关系,再进一步探讨不同BMI对乳腺癌发病的截断效应,采用Begg's检验评估发表偏倚。结果共纳入8篇文献,共103 141人。绝经前组合并后的效应量RR值为1.10(95%CI:0.95~1.27),绝经后组合并后的效应量RR值为1.52(95%CI:1.31~1.75),绝经前、后均未发现剂量-反应关系(X~2=1.95,PLinearity=0.16;=2.02,PNonlinearity=0.57)。相对于参照组(18.5 kg/m~2BMI≤24kg/m~2),绝经后超重人群(24kg/m~2BMI≤28kg/m~2)其乳腺癌发病风险RR值为1.33(95%CI:1.10~1.60),肥胖人群(BMI28 kg/m~2)为1.83(95%CI:1.46~2.29)。Begg's检验的Z=0.82,P=0.41,所纳入分析的文献不存在发表偏倚。结论在中国,BMI升高可增加绝经后女性乳腺癌的发病风险,而在绝经前女性人群中尚未发现此关联。
[Abstract]:Objective to investigate the relationship between BMI and breast cancer in Chinese women with different menopausal status. Methods Pub Med,EMBASE, Wanfang database, Weipu database and (CNKI), database were searched by computer. From January 2000 to February 2017, the literature on the relationship between (BMI) grouping and breast cancer incidence in Chinese women was collected from January 2000 to February 2017. Stata12.0 was used for Meta analysis. On the basis of the overall effect relationship, linear and nonlinear models were fitted. If no dose-response relationship was found, the truncation effect of different BMI on breast cancer was further discussed. Publication bias was evaluated by Begg's test. Results A total of 103 141 people were included in 8 articles. The RR value of postmenopausal group was 1.10 (95%CI:0.95~1.27), the RR value of postmenopausal group was 1.52 (95%CI:1.31~1.75), and that of premenopausal group was 1.10 (95%CI:0.95~1.27). No dose-response relationship was found after the experiment. = 2.02 P nonlinearity 0.57). Compared with the control group (18. 5 kg/m~2BMI 鈮，

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