食管鳞状细胞癌组织中EGFR和P-EGFR的表达及其临床意义

发布时间：2018-11-22 16:24

【摘要】：目的:探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)和磷酸化表皮生长因子受体(phosphorylated epidermal growth factor receptor,P-EGFR)在食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC,食管鳞癌)中的表达与其临床病理特征的相关性及预后的关系。方法:采用免疫组织化学方法(immunohistochemistry,IHC)检测100例食管鳞癌患者癌组织及癌旁组织中EGFR和P-EGFR的表达水平,分析食管鳞癌组织中EGFR和P-EGFR的表达水平与食管鳞癌患者临床病理特征及预后的关系。结果:(1)EGFR在食管鳞癌组织和癌旁组织中的阳性表达率分别为72%(72/100)、17%(17/100),二者相比差异具有统计学意义(χ2=75.531,P0.01);P-EGFR在食管鳞癌及其癌旁组织中的阳性表达率分别为64%(64/100)、12%(12/100),两者相比差异有统计学意义(χ2=74.123,P0.01)。(2)EGFR蛋白阳性表达水平与食管鳞癌患者的分化程度、pT分期及淋巴结转移有关(均P0.05),但与性别、年龄、pTNM分期均无关(均P0.05);P-EGFR蛋白的表达水平与食管鳞癌患者的分化程度有关(P0.05),而与性别、年龄、pT分期、pN分期、pTNM分期均无关(均P0.05)。此外,EGFR与P-EGFR蛋白阳性表达呈正相关。(3)Kaplan-Meier生存分析显示与EGFR和P-EGFR高表达者相比,EGFR与P-EGFR低表达患者总生存期及无病生存期均优于高表达者(均P0.05)。结论:EGFR和P-EGFR的表达水平的高低与患者总生存期及无病生存期均存在显著相关性,提示可能是预测食管鳞癌患者预后的预测因子。
[Abstract]:Objective: to investigate the role of epidermal growth factor receptor (epidermal growth factor receptor,EGFR) and phosphorylated epidermal growth factor receptor (phosphorylated epidermal growth factor receptor,P-EGFR) in esophageal squamous cell carcinoma (esophageal squamous cell carcinoma,ESCC,). The relationship between expression and clinicopathological features and prognosis of esophageal squamous cell carcinoma. Methods: immunohistochemical method (immunohistochemistry,IHC) was used to detect the expression of EGFR and P-EGFR in carcinoma tissues and adjacent tissues of 100 patients with esophageal squamous cell carcinoma. To analyze the relationship between the expression of EGFR and P-EGFR in esophageal squamous cell carcinoma and the clinicopathological features and prognosis of esophageal squamous cell carcinoma. Results: (1) the positive expression rates of EGFR in esophageal squamous cell carcinoma and paracancerous tissues were 72% (72 / 100) and 17% (17 / 100), respectively. The positive expression rates of P-EGFR in esophageal squamous cell carcinoma and its adjacent tissues were 64% (64 / 100) and 12% (12 / 100), respectively. The positive expression of EGFR protein was related to the differentiation degree, pT stage and lymph node metastasis of esophageal squamous cell carcinoma (P0.01). (2) (P0.05), but not to sex, age and pTNM stage (P0.05). The expression of P-EGFR protein was related to the differentiation of esophageal squamous cell carcinoma (P0.05), but not to sex, age, pT stage, pN stage and pTNM stage (P0.05). In addition, there was a positive correlation between the expression of EGFR and P-EGFR protein. (3) Kaplan-Meier survival analysis showed that the positive expression of EGFR and P-EGFR was higher than that of EGFR. The total survival time and disease-free survival of patients with low expression of EGFR and P-EGFR were better than those with high expression (P0.05). Conclusion: the expression of EGFR and P-EGFR is significantly correlated with the total survival and disease-free survival, suggesting that the expression of EGFR and P-EGFR may be a predictor of prognosis in patients with esophageal squamous cell carcinoma.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.1

【参考文献】

相关期刊论文 前10条

1 左婷婷;郑荣寿;曾红梅;张思维;陈万青;赫捷;;中国食管癌发病状况与趋势分析[J];中华肿瘤杂志;2016年09期

2 刘蕾;李席如;胡蕴慧;张瑾;;TOP2A、EGFR基因表达与三阴性乳腺癌TE方案新辅助化疗疗效的相关性[J];中华医学杂志;2016年12期

3 吴伟;;磷酸化表皮生长因子受体与鼻咽癌患者预后关系的研究[J];中国医学创新;2015年30期

4 刘芳芳;李晓雅;黄选东;;EGFR磷酸化水平与乳腺癌术后生存期的关系评价[J];徐州医学院学报;2015年09期

5 王豪杰;施巩宁;赵辉;梁冰;车建波;王一;;RhoE与EGFR在食管鳞癌中表达的研究[J];临床外科杂志;2014年12期

6 李瑾昱;焦顺昌;张国庆;孙胜杰;;表皮生长因子受体表达水平对西妥昔单抗及其介导的抗体依赖的细胞介导的细胞毒作用杀伤肺腺癌A549细胞的影响[J];中国医学科学院学报;2014年02期

7 马玲玲;王多明;吾甫尔·艾克木;吴冉;张烁;王若峥;;头颈部鳞癌人乳头瘤病毒感染与p16和表皮生长因子受体表达及患者预后的关系[J];中华肿瘤杂志;2014年01期

8 季现秀;范理宏;;磷酸化AKT与磷酸化EGFR在非小细胞肺癌中的表达及意义[J];肿瘤;2010年04期

9 梁朝晖;张维彬;胡少为;李伟平;;食管癌组织中表皮生长因子受体和上皮钙粘附素的表达及其临床意义[J];实用医学杂志;2009年08期

10 Krause DS ,Van Etten RA ,黄艳;癌症治疗的靶点——酪氨酸激酶[J];中国处方药;2005年10期

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