朗格汉斯细胞组织细胞增生症皮损组织炎症反应模式和临床表现的关系
发布时间：2018-11-23 11:44
【摘要】：目的对LCH皮损组织炎症反应模式进行分析,探讨其病理特征与临床表现、预后的关系。方法选择有皮损表现的25例LCH患者作为研究对象,分析患者皮损组织炎症反应模式,通过免疫组化技术检测患者皮损组织中ki-67、CD163的表达情况,采集分析患者临床资料,电话随访患者治疗情况以及预后。所得数据用SPSS15.0统计软件进行统计学分析。结果(1)LCH皮损组织中有两种炎症反应模式,一种为表现为朗格汉斯组织细胞周围多量组织细胞、淋巴细胞浸润模式,另一种表现为朗格汉斯组织细胞周围稀疏组织细胞、淋巴细胞浸润模式。(2)25例LCH皮损组织中ki-67阳性密度平均为16.99%?12.02%,浸润炎细胞CD163阳性密度为16.71%?12.17%。在仅累及皮肤的SS-LCH中,ki-67及CD163阳性密度均值分别为14.13%?8.47%和24.64%?13.91%;累及皮肤和内脏器官的MS-LCH中ki-67及CD163阳性密度均值分别为17.94%?13.02%和14.06%?10.61%。SS-LCH与MS-LCH比较,ki-67阳性细胞浸润密度差异无统计学意义(P0.05),CD163阳性细胞浸润密度差异具有统计学意义(P0.05)。结论(1)LCH皮损组织中朗格汉斯组织细胞增殖指数水平较低,增殖指数水平与患者内脏是否累及无相关性。(2)CD163阳性炎性细胞浸润密度可能与LCH侵袭进展相关。
[Abstract]:Objective to study the relationship between pathological features and clinical manifestations and prognosis of LCH lesions. Methods 25 cases of LCH patients with lesions were selected as the study objects. The inflammatory response patterns in the lesions were analyzed. The expression of ki-67,CD163 in the lesions was detected by immunohistochemical technique, and the clinical data of the patients were collected and analyzed. The treatment and prognosis of the patients were followed up by telephone. The data were analyzed by SPSS15.0 software. Results (1) there were two inflammatory response patterns in the lesions of LCH, one was the infiltration of lymphocytes around Langerhans tissue cells, the other was sparse tissue cells around Langerhans tissue cells. (2) in 25 cases of LCH, the average positive density of ki-67 was 16.990.The positive density of CD163 in infiltrative cells was 16.71 and 12.172.The positive density of CD163 in infiltrative cells was 16.71 and 12.17 respectively. In SS-LCH with only skin involvement, the average positive densities of ki-67 and CD163 were 14.138.47% and 24.64%, 13.91%, respectively. The average positive densities of ki-67 and CD163 in MS-LCH involving skin and visceral organs were 17.9413.02% and 13.02%, respectively, and 14.06%?10.61%.SS-LCH were compared with MS-LCH. There was no significant difference in the infiltration density of ki-67 positive cells (P0.05), but there was significant difference in the infiltration density of CD163 positive cells (P0.05). Conclusion (1) the level of Langerhans' cell proliferation index in LCH lesions is low, and there is no correlation between the proliferation index and visceral involvement. (2) the density of CD163 positive inflammatory cells infiltration may be related to the invasion and progression of LCH.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R733.3
本文编号：2351483
[Abstract]:Objective to study the relationship between pathological features and clinical manifestations and prognosis of LCH lesions. Methods 25 cases of LCH patients with lesions were selected as the study objects. The inflammatory response patterns in the lesions were analyzed. The expression of ki-67,CD163 in the lesions was detected by immunohistochemical technique, and the clinical data of the patients were collected and analyzed. The treatment and prognosis of the patients were followed up by telephone. The data were analyzed by SPSS15.0 software. Results (1) there were two inflammatory response patterns in the lesions of LCH, one was the infiltration of lymphocytes around Langerhans tissue cells, the other was sparse tissue cells around Langerhans tissue cells. (2) in 25 cases of LCH, the average positive density of ki-67 was 16.990.The positive density of CD163 in infiltrative cells was 16.71 and 12.172.The positive density of CD163 in infiltrative cells was 16.71 and 12.17 respectively. In SS-LCH with only skin involvement, the average positive densities of ki-67 and CD163 were 14.138.47% and 24.64%, 13.91%, respectively. The average positive densities of ki-67 and CD163 in MS-LCH involving skin and visceral organs were 17.9413.02% and 13.02%, respectively, and 14.06%?10.61%.SS-LCH were compared with MS-LCH. There was no significant difference in the infiltration density of ki-67 positive cells (P0.05), but there was significant difference in the infiltration density of CD163 positive cells (P0.05). Conclusion (1) the level of Langerhans' cell proliferation index in LCH lesions is low, and there is no correlation between the proliferation index and visceral involvement. (2) the density of CD163 positive inflammatory cells infiltration may be related to the invasion and progression of LCH.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R733.3
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