复方丹参注射液联合伊马替尼对急性淋巴细胞白血病患者P-糖蛋白、P53蛋白水平及心血管功能的影响
发布时间：2018-11-25 09:22
【摘要】：目的:探讨复方丹参注射液联合伊马替尼对急性淋巴细胞白血病(ALL)患者P-糖蛋白、P53蛋白水平及心血管功能的影响。方法:随机数字表格法将纳入标准的80例ALL患者分为对照组与观察组,各40例,所有患者均接受VDCP化疗方案治疗,此外对照组加以伊马替尼治疗,观察组则加以复方丹参注射液联合伊马替尼治疗,比较两组近期疗效、不良反应、治疗前后外周血象、免疫功能及心率变异性(HRV)指标,同时治疗前后通过流式细胞仪测定P-糖蛋白及P53蛋白水平。结果:观察组治疗有效率90.00%,较对照组的80.00%差异无统计学意义(P0.05)。与治疗前比较,治疗后两组WBC水平显著下降,Hb、PLT、RBC水平显著上升(P0.05)。观察组治疗后WBC、Hb、RBC、CD_3~+、CD_4~+、CD_4~+/CD_8~+、SDNN、SDANN、RMSSD、PNN50水平均明显高于对照组(P0.05)。观察组治疗后P53阳性表达率较治疗前明显下降,较对照组明显低(P0.05)。观察组肝功能异常发生率明显低于对照组(P0.05)。结论:复方丹参注射液联合伊马替尼治疗ALL疗效明确,能有效减少伊马替尼+化疗不良反应,降低P-糖蛋白及P53蛋白阳性表达率,且对患者免疫功能、心率变异性有一定的改善作用。
[Abstract]:Aim: to investigate the effects of compound salvia miltiorrhiza injection combined with imatinib on the levels of P glycoprotein, p53 protein and cardiovascular function in patients with acute lymphoblastic leukemia (ALL). Methods: 80 patients with ALL were randomly divided into two groups: control group (n = 40) and observation group (n = 40). All patients were treated with VDCP chemotherapy regimen, and the control group were treated with imatinib. The observation group was treated with compound salvia miltiorrhiza injection combined with imatinib. The short-term curative effect, adverse reaction, peripheral blood picture, immune function and (HRV) index of heart rate variability before and after treatment were compared between the two groups. At the same time, the levels of P-glycoprotein and P 53 protein were measured by flow cytometry before and after treatment. Results: the effective rate of treatment in the observation group was 90.00%, which was not significantly different from that in the control group (80.00%) (P0.05). Compared with before treatment, the level of WBC decreased significantly and the level of Hb,PLT,RBC increased significantly in the two groups after treatment (P0.05). The levels of WBC,Hb,RBC,CD_3~, CD_4~, CD_4~ / CD_8~ and SDNN,SDANN,RMSSD,PNN50 in the observation group were significantly higher than those in the control group (P0.05). After treatment, the positive expression rate of p53 in the observation group was significantly lower than that in the control group (P0.05). The incidence of abnormal liver function in the observation group was significantly lower than that in the control group (P0.05). Conclusion: compound salvia miltiorrhiza injection combined with imatinib is effective in the treatment of ALL. It can effectively reduce the adverse reaction of imatinib chemotherapy, decrease the positive rate of expression of P-glycoprotein and p53 protein, and can improve the immune function of the patients. Heart rate variability can be improved to some extent.
【作者单位】： 湖州市中医院内科;
【基金】：浙江省自然科学基金项目(2015348572)
【分类号】：R733.71
[Abstract]:Aim: to investigate the effects of compound salvia miltiorrhiza injection combined with imatinib on the levels of P glycoprotein, p53 protein and cardiovascular function in patients with acute lymphoblastic leukemia (ALL). Methods: 80 patients with ALL were randomly divided into two groups: control group (n = 40) and observation group (n = 40). All patients were treated with VDCP chemotherapy regimen, and the control group were treated with imatinib. The observation group was treated with compound salvia miltiorrhiza injection combined with imatinib. The short-term curative effect, adverse reaction, peripheral blood picture, immune function and (HRV) index of heart rate variability before and after treatment were compared between the two groups. At the same time, the levels of P-glycoprotein and P 53 protein were measured by flow cytometry before and after treatment. Results: the effective rate of treatment in the observation group was 90.00%, which was not significantly different from that in the control group (80.00%) (P0.05). Compared with before treatment, the level of WBC decreased significantly and the level of Hb,PLT,RBC increased significantly in the two groups after treatment (P0.05). The levels of WBC,Hb,RBC,CD_3~, CD_4~, CD_4~ / CD_8~ and SDNN,SDANN,RMSSD,PNN50 in the observation group were significantly higher than those in the control group (P0.05). After treatment, the positive expression rate of p53 in the observation group was significantly lower than that in the control group (P0.05). The incidence of abnormal liver function in the observation group was significantly lower than that in the control group (P0.05). Conclusion: compound salvia miltiorrhiza injection combined with imatinib is effective in the treatment of ALL. It can effectively reduce the adverse reaction of imatinib chemotherapy, decrease the positive rate of expression of P-glycoprotein and p53 protein, and can improve the immune function of the patients. Heart rate variability can be improved to some extent.
【作者单位】： 湖州市中医院内科;
【基金】：浙江省自然科学基金项目(2015348572)
【分类号】：R733.71
【参考文献】
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1 刘奎;郭sヂ，
本文编号：2355601
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