LINE-1编码的逆转录酶在肿瘤形成过程中的作用
发布时间：2018-11-25 15:51
【摘要】：逆转录转座子LINE-1是人类基因组中最大的转座子家族,约有500 000个拷贝,占人类基因组总量的17%,同时它也是人类基因组中唯一具有自主转座能力的转座子。LINE-1编码的逆转录酶是LINE-1转座所必需,近年来的研究表明该酶在包括肿瘤形成等重要的病理或生理过程中都发挥着重要的作用。抑制该酶的活性可阻滞肿瘤发展的进程、恢复肿瘤细胞的分化状态以及改变肿瘤细胞的转录组谱。本文根据近年来对LINE-1编码的逆转录酶的研究进展,介绍该酶通过对非编码RNA转录组谱的调控在肿瘤形成过程中产生的作用,以期为肿瘤的早期诊断以及抗肿瘤药物的开发提供一些线索。
[Abstract]:Retrotransposon LINE-1 is the largest transposon family in the human genome, with about 500,000 copies, accounting for 17 percent of the total human genome. It is also the only transposon in the human genome with autonomous transposon. The reverse transcriptase encoded by LINE-1 is necessary for LINE-1 transposition. Recent studies have shown that the enzyme plays an important role in pathological and physiological processes, including tumor formation. Inhibiting the activity of the enzyme can block the progress of tumor development, restore the differentiation of tumor cells and change the transcriptional spectrum of tumor cells. In this paper, according to the research progress of LINE-1 encoded reverse transcriptase in recent years, the role of this enzyme in tumorigenesis through the regulation of non-coding RNA transcriptome spectrum is introduced. In order to provide some clues for the early diagnosis of tumor and the development of anti-tumor drugs.
【作者单位】： 中国医学科学院&北京协和医学院医药生物技术研究所免疫生物学室;
【基金】：国家自然科学基金项目(编号:31270210)资助~~
【分类号】：R730.2
本文编号：2356662
[Abstract]:Retrotransposon LINE-1 is the largest transposon family in the human genome, with about 500,000 copies, accounting for 17 percent of the total human genome. It is also the only transposon in the human genome with autonomous transposon. The reverse transcriptase encoded by LINE-1 is necessary for LINE-1 transposition. Recent studies have shown that the enzyme plays an important role in pathological and physiological processes, including tumor formation. Inhibiting the activity of the enzyme can block the progress of tumor development, restore the differentiation of tumor cells and change the transcriptional spectrum of tumor cells. In this paper, according to the research progress of LINE-1 encoded reverse transcriptase in recent years, the role of this enzyme in tumorigenesis through the regulation of non-coding RNA transcriptome spectrum is introduced. In order to provide some clues for the early diagnosis of tumor and the development of anti-tumor drugs.
【作者单位】： 中国医学科学院&北京协和医学院医药生物技术研究所免疫生物学室;
【基金】：国家自然科学基金项目(编号:31270210)资助~~
【分类号】：R730.2
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