胃肠癌MTHFR基因C677T多态性与5-氟尿嘧啶化疗方案治疗敏感性的相关性Meta分析

发布时间：2018-11-27 17:12

【摘要】：目的 :系统评价胃肠癌组织中亚甲基四氢叶酸还原酶(methylenetetrahydrofolate reductase,MTHFR)基因C677T位点多态性与含5-氟尿嘧啶化疗方案治疗敏感性的相关性。方法:系统检索PubMed、EBSCO、Web of Science、Cochrane Library、中国生物医学文献数据库、中国知网、维普以及万方数据库,收集有关MTHFR C677T基因多态性与含5-氟尿嘧啶化疗方案治疗胃肠癌敏感性关系的研究文献,检索时限均从各数据库建库至2016年12月。由2位评价者按照纳入与排除标准独立筛选文献、提取资料后,采用Rev Man 5.3软件进行Meta分析,并采用STATA 12.0统计学软件进行敏感性分析和发表偏倚评估。结果:共纳入11项研究,共1 267例胃肠癌患者。携带T等位基因的患者对含5-氟尿嘧啶化疗方案的敏感性明显高于携带C等位基因的患者[比值比(odds ratio,OR)=5.31,95%可信区间(confidence interval,CI)为3.23~8.73,P0.001]。TT基因型患者对化疗方案的敏感性明显高于CC基因型患者(OR=4.87,95%CI为2.18~10.86,P0.001)。TT+TC基因型患者对化疗方案的敏感性明显高于CC基因型患者(OR=0.52,95%CI为0.33~0.84,P=0.007)。TT基因型患者对化疗方案的敏感性明显高于CC+TC基因型患者(OR=4.39,95%CI为2.07~9.32,P0.001)。结论:胃肠癌患者的MTHFR C677T基因多态性与含5-氟尿嘧啶化疗方案治疗敏感性明显相关。
[Abstract]:Objective: to evaluate the relationship between C677T polymorphism of methylene tetrahydrofolate reductase (methylenetetrahydrofolate reductase,MTHFR) gene and the sensitivity of 5-fluorouracil chemotherapy regimen in gastrointestinal carcinoma. Methods: PubMed,EBSCO,Web of Science,Cochrane Library, Chinese Biomedical Literature Database, China knowledge Network, Weip and Wanfang databases were searched systematically. The relationship between the polymorphism of MTHFR C677T gene and the sensitivity of chemotherapy regimen containing 5-fluorouracil to gastrointestinal cancer was collected. The searching time was from the establishment of each database to December 2016. According to the inclusion and exclusion criteria, two evaluators independently sifted the literature. After extracting the data, Meta analysis was carried out by Rev Man 5.3 software, and sensitivity analysis and publication bias evaluation were performed by STATA 12.0 statistical software. Results: a total of 1 267 patients with gastrointestinal carcinoma were included in 11 studies. The sensitivity of patients with T allele to 5-fluorouracil chemotherapy regimen was significantly higher than that of patients with C allele [ratio (odds ratio,OR) = 5.31% 95% confidence interval (confidence interval,CI) = 3.23 ~ 8.73]. P0.001. The sensitivity of patients with TT genotype to chemotherapy regimen was significantly higher than that of patients with CC genotype (OR=4.87,95%CI = 2.18 卤10.86). The sensitivity of patients with P0.001). TT TC genotype to chemotherapy regimen was significantly higher than that of CC genotype patients (OR=0.52,95%CI = 0.330.84). The sensitivity of P0. 007). TT genotype patients to chemotherapy regimen was significantly higher than that of CC TC genotype patients (OR=4.39,95%CI was 2. 07 ~ 9. 32% P0.001). Conclusion: the polymorphism of MTHFR C 677T gene in patients with gastrointestinal carcinoma is associated with the sensitivity of chemotherapy regimen containing 5 fluorouracil.
【作者单位】：郑州大学第一附属医院药学部;漯河医专第二附属医院内四科;郑州大学第一附属医院肿瘤科;郑州大学第一附属医院生物细胞治疗中心;郑州大学第一附属医院综合ICU;
【分类号】：R735

【相似文献】