OLC1蛋白在NSCLC患者组织中的表达情况及其与预后的关系
发布时间：2018-12-14 01:49
【摘要】：背景与目的OLC1(overexpressed in lung cancer 1)是一个新型肺癌相关基因,前期的研究发现,在肺鳞癌、腺癌、小细胞癌组织中均有较高表达,OLC1蛋白在肺癌患者外周血浆中的表达显著高于正常人,并可作为肺癌的辅助诊断的候选标志物。OLC1在食管鳞癌、卵巢癌、乳腺癌、结直肠癌组织中也有较高表达,并与不良预后相关,但OLC1与肺癌患者预后的关系一直缺乏相关研究。本研究通过检测OLC1在非小细胞肺癌(NSCLC)患者癌组织中的蛋白表达情况,结合预后资料,分析OLC1的过表达与肺癌患者预后的关系。方法分别对包含75例鳞癌和90例腺癌的癌组织和癌旁组织的组织芯片以及33例鳞癌组织切片进行免疫组化染色,检测OLC1蛋白的表达水平,分析其在组织中的表达与临床特征及预后的关系。结果OLC1在腺癌患者癌组织中的过表达率(87.5%)明显高于鳞癌(55.3%,P0.001)。OLC1在腺癌患者癌组织中的过表达与预后无显著相关性,在鳞癌组织中的过表达与不良预后相关,单因素Kaplan-Meier生存分析提示OLC1过表达的患者具有更差的预后(P=0.042),多因素Cox回归分析显示两组之间的生存差异无统计学意义(HR=2.048,95%CI 1.00-4.19,P=0.05)。OLC1在年龄≥60岁的患者中更易出现过表达(P=0.002),OLC1与年龄≥60岁共同作为危险因素时,患者的预后显著变差(HR=5.125,95%CI 1.756-14.96,P=0.003)。结论OLC1在腺癌组织中的过表达率明显高于鳞癌,但OLC1在癌组织中的过表达与腺癌患者的预后关系不明显;OLC1在≥60岁的鳞癌患者组织中更易表达,并可能与年龄一起共同影响鳞癌患者的预后,但在癌组织中的过表达不足以作为影响肺鳞癌患者预后的独立危险因素。
[Abstract]:Background & objective OLC1 (overexpressed in lung cancer 1 is a novel lung cancer associated gene. Previous studies have found that it is highly expressed in squamous cell carcinoma, adenocarcinoma and small cell carcinoma. The expression of OLC1 protein in peripheral plasma of lung cancer patients was significantly higher than that in normal controls, and could be used as a candidate marker for auxiliary diagnosis of lung cancer. OLC1 was also highly expressed in esophageal squamous cell carcinoma, ovarian cancer, breast cancer and colorectal cancer. But the relationship between OLC1 and prognosis of lung cancer patients has not been studied. In this study, we examined the expression of OLC1 protein in non-small cell lung cancer (NSCLC) patients with (NSCLC), and analyzed the relationship between the overexpression of OLC1 and the prognosis of NSCLC patients. Methods the tissue microarray of 75 cases of squamous cell carcinoma and 90 cases of adenocarcinoma and 33 cases of squamous cell carcinoma were stained with immunohistochemical staining to detect the expression of OLC1 protein. To analyze the relationship between its expression and clinical features and prognosis. Results the overexpression rate of OLC1 in adenocarcinoma (87.5%) was significantly higher than that in squamous cell carcinoma (55.3p0.001). There was no significant correlation between the overexpression of OLC1 and prognosis in adenocarcinoma. Overexpression in squamous cell carcinoma was associated with poor prognosis. Univariate Kaplan-Meier survival analysis suggested that patients with overexpression of OLC1 had a worse prognosis (P0. 042). Multivariate Cox regression analysis showed that there was no significant difference in survival between the two groups (HR=2.048,95%CI 1.00-4.19 P0. 05). OLC1 was more likely to be expressed in patients with age 鈮，
本文编号：2377684
[Abstract]:Background & objective OLC1 (overexpressed in lung cancer 1 is a novel lung cancer associated gene. Previous studies have found that it is highly expressed in squamous cell carcinoma, adenocarcinoma and small cell carcinoma. The expression of OLC1 protein in peripheral plasma of lung cancer patients was significantly higher than that in normal controls, and could be used as a candidate marker for auxiliary diagnosis of lung cancer. OLC1 was also highly expressed in esophageal squamous cell carcinoma, ovarian cancer, breast cancer and colorectal cancer. But the relationship between OLC1 and prognosis of lung cancer patients has not been studied. In this study, we examined the expression of OLC1 protein in non-small cell lung cancer (NSCLC) patients with (NSCLC), and analyzed the relationship between the overexpression of OLC1 and the prognosis of NSCLC patients. Methods the tissue microarray of 75 cases of squamous cell carcinoma and 90 cases of adenocarcinoma and 33 cases of squamous cell carcinoma were stained with immunohistochemical staining to detect the expression of OLC1 protein. To analyze the relationship between its expression and clinical features and prognosis. Results the overexpression rate of OLC1 in adenocarcinoma (87.5%) was significantly higher than that in squamous cell carcinoma (55.3p0.001). There was no significant correlation between the overexpression of OLC1 and prognosis in adenocarcinoma. Overexpression in squamous cell carcinoma was associated with poor prognosis. Univariate Kaplan-Meier survival analysis suggested that patients with overexpression of OLC1 had a worse prognosis (P0. 042). Multivariate Cox regression analysis showed that there was no significant difference in survival between the two groups (HR=2.048,95%CI 1.00-4.19 P0. 05). OLC1 was more likely to be expressed in patients with age 鈮，
本文编号：2377684
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