320例多发性骨髓瘤校正血钙的临床意义

发布时间：2018-12-17 20:28

【摘要】：目的:分析多发性骨髓瘤患者校正血钙的临床意义。方法:检测320例初发多发性骨髓瘤患者的血钙水平,用同时采集静脉血所得血清白蛋白浓度进行校正,分析校正前后血钙浓度的差异。结果:320例多发性骨髓瘤患者血钙浓度为2.34±0.15 mmol/L,校正后血钙浓度为2.6±0.17 mmol/L,高钙血症患者由11.3%升至校正后的23.1%,低钙血症患者由42.8%下降至校正后的7.8%,血钙的正常患者例数增加。Ⅰ、Ⅱ和Ⅲ期病人的血钙水平在经白蛋白校正前后均有显著性差异(P0.05)。320例MM患者贫血发生率为80%,肾功能不全发生率为20.9%,骨髓瘤骨病发生率为68.8%,贫血、肾功能不全、骨髓瘤骨病患者血钙浓度均高于正常组,且校正后差异更显著。接受化疗的患者220例,中位PFS为15个月,中位OS为20个月,高钙血症患者PFS及OS缩短,校正后PFS及OS明显缩短,具有显著性差异(P0.001)。结论:校正血钙能更敏感地反映疾病的严重程度,具有更好的预后判断作用。
[Abstract]:Objective: to analyze the clinical significance of corrected serum calcium in patients with multiple myeloma. Methods: the serum calcium levels in 320 patients with primary multiple myeloma were measured. The serum albumin concentration was corrected by collecting venous blood simultaneously. The difference of serum calcium concentration before and after correction was analyzed. Results: the serum calcium concentration of 320 patients with multiple myeloma was 2.34 卤0.15 mmol/L, corrected, and the serum calcium concentration was 2.6 卤0.17 mmol/L, from 11.3% to 23.1%. The number of patients with hypocalcemia decreased from 42.8% to 7.8 after correction, and the number of normal patients with serum calcium increased. The serum calcium levels of stage 鈪，

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