原发浆细胞白血病诊疗进展
发布时间：2019-01-04 13:33
【摘要】：原发浆细胞白血病(primary plasma cell leukemia,PPCL)属于高度侵袭性的浆细胞疾病。与多发性骨髓瘤相比,PPCL有其独特的细胞遗传学及分子生物学特征。化疗,新药如硼替佐米,免疫调节剂及造血干细胞移植的联合应用提高了PPCL患者的预后和生存,而不同的遗传及基因表达谱亦与不同预后相关。处于临床试验阶段的部分靶向药物如CD38单克隆抗体和CD138-CAR-T等也为PPCL的治疗提供了新的方向。本文就近年来PPCL的诊断和治疗的最新进展作一综述,讨论的主要问题包括有PPCL的诊断,PPCL的临床及生化特征,PPCL的治疗及预后和PPCL新药研究现状等。
[Abstract]:Primary plasmacytic leukemia (primary plasma cell leukemia,PPCL) is a highly invasive plasmacytic disease. Compared with multiple myeloma, PPCL has its unique cytogenetic and molecular biological characteristics. The combination of chemotherapy, new drugs such as bortezomil, immunomodulator and hematopoietic stem cell transplantation improved the prognosis and survival of PPCL patients, and different genetic and gene expression profiles were also associated with different prognosis. Some targeted drugs, such as CD38 monoclonal antibody and CD138-CAR-T, also provide a new direction for the treatment of PPCL. This paper reviews the recent advances in the diagnosis and treatment of PPCL. The main issues discussed include the diagnosis of PPCL, the clinical and biochemical characteristics of PPCL, the treatment and prognosis of PPCL, and the current status of new PPCL drugs.
【作者单位】： 南京医科大学附属无锡市人民医院血液科;南京医科大学第一附属医院血液科;
【分类号】：R733.7
本文编号：2400357
[Abstract]:Primary plasmacytic leukemia (primary plasma cell leukemia,PPCL) is a highly invasive plasmacytic disease. Compared with multiple myeloma, PPCL has its unique cytogenetic and molecular biological characteristics. The combination of chemotherapy, new drugs such as bortezomil, immunomodulator and hematopoietic stem cell transplantation improved the prognosis and survival of PPCL patients, and different genetic and gene expression profiles were also associated with different prognosis. Some targeted drugs, such as CD38 monoclonal antibody and CD138-CAR-T, also provide a new direction for the treatment of PPCL. This paper reviews the recent advances in the diagnosis and treatment of PPCL. The main issues discussed include the diagnosis of PPCL, the clinical and biochemical characteristics of PPCL, the treatment and prognosis of PPCL, and the current status of new PPCL drugs.
【作者单位】： 南京医科大学附属无锡市人民医院血液科;南京医科大学第一附属医院血液科;
【分类号】：R733.7
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