Cullin-RING E3泛素连接酶及其抑制剂在肿瘤治疗中的研究进展
发布时间：2019-01-25 10:40
【摘要】：Cullin-RING泛素连接酶(cullin-r ING ligase,CRL)是人体内数量最多的一类泛素连接酶的统称,由cullin蛋白、RING蛋白及底物识别亚基组成。它们通过与数百种底物相互作用,形成数量庞大的CRL复合体并调控细胞内蛋白分子的泛素化降解过程。作者对CRL及其抑制剂在肿瘤治疗中的研究进展作一综述。
[Abstract]:Cullin-RING ubiquitin ligase (cullin-r ING ligase,CRL), which is composed of cullin protein, RING protein and substrate recognition subunit, is the most abundant ubiquitin ligase in human body. By interacting with hundreds of substrates, they form a large number of CRL complexes and regulate the degradation of Ubiquitin molecules in cells. This paper reviews the research progress of CRL and its inhibitors in tumor therapy.
【作者单位】： 东南大学医学院;南京市第一医院;
【基金】：国家自然科学基金资助项目(81272469)
【分类号】：R730.5
[Abstract]:Cullin-RING ubiquitin ligase (cullin-r ING ligase,CRL), which is composed of cullin protein, RING protein and substrate recognition subunit, is the most abundant ubiquitin ligase in human body. By interacting with hundreds of substrates, they form a large number of CRL complexes and regulate the degradation of Ubiquitin molecules in cells. This paper reviews the research progress of CRL and its inhibitors in tumor therapy.
【作者单位】： 东南大学医学院;南京市第一医院;
【基金】：国家自然科学基金资助项目(81272469)
【分类号】：R730.5
【相似文献】
相关期刊论文 前9条
1 汤颖;乐s，
本文编号：2415055
本文链接：https://www.wllwen.com/yixuelunwen/zlx/2415055.html
