肾脏甲状腺滤泡样肾细胞癌2例并文献复习

发布时间：2019-02-08 21:03

【摘要】：目的探讨肾脏甲状腺滤泡样肾细胞癌(thyroid-like follicular renal cell carcinoma)的临床病理学特征、免疫表型及鉴别诊断。方法回顾性分析2例甲状腺滤泡样肾细胞癌的临床病理学和影像学资料,将肿瘤标本行常规病理组织学和免疫组化检查,并复习相关文献。结果 2例患者均为女性,年龄分别为25、68岁,临床均以体检时发现肾脏肿块就诊。肿瘤位于肾脏实质内,边界较清楚。镜下见肿瘤由大小不一的滤泡样结构组成,滤泡腔内含嗜酸性胶质样物。免疫表型:肿瘤细胞CK广谱、CK7、EMA弥漫强阳性,CD10散在弱阳性,RCC、TTF-1、TG、AMACR、NSE、Syn和Cg A均阴性。结论肾脏甲状腺滤泡样肾细胞癌是一种罕见的、低度恶性潜能的肾上皮来源的肿瘤,WHO(2016)将其列为肾细胞癌的暂定亚型。确诊主要依赖特征性的组织学表现(内含胶质样物的滤泡结构),预后可能有别于其他肾细胞癌类型。临床病理医师应提高认识水平,避免误诊、误治。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype and differential diagnosis of renal follicular renal cell carcinoma (thyroid-like follicular renal cell carcinoma). Methods the clinicopathological and imaging data of 2 cases of thyroid follicular renal cell carcinoma were analyzed retrospectively. Results the two patients were all female, aged 25 to 68 years. All the patients were diagnosed with renal mass at the time of physical examination. The tumor is located in the renal parenchyma and the boundary is clear. Microscopically, the tumor was composed of follicle-like structure of different size, and the acidophilic colloid was found in the follicular cavity. Immunophenotypes: tumor cell CK broad spectrum, CK7,EMA diffuse strong positive, CD10 scattered weakly positive, RCC,TTF-1,TG,AMACR,NSE,Syn and Cg A negative. Conclusion Renal follicular renal cell carcinoma (, WHO (2016) is a rare, low-grade malignant epithelial tumor that is classified as a provisional subtype of renal cell carcinoma. The diagnosis mainly depends on the characteristic histological features (the follicular structure containing glial substance) and the prognosis may be different from other renal cell carcinoma types. Clinicopathologists should improve their understanding and avoid misdiagnosis and mistreatment.
【作者单位】：山东省东营市胜利油田中心医院病理科;山东省临朐县人民医院病理科;山东省东营市胜利油田中心医院医学影像科;浙江省绍兴市人民医院病理科;
【分类号】：R737.11

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