三阴型乳腺癌中CD47的表达及其临床意义
发布时间：2019-02-16 14:05
【摘要】：目的探讨CD47在三阴型乳腺癌(triple negative breast carcinoma,TNBC)中的表达及其与临床病理特征的相关性。方法运用组织芯片结合免疫组化Bond Polymer Refine Detection法对185例TNBC及35例非三阴型乳腺癌(non-triple negative breast carcinoma,NTNBC)进行染色,观察CD47在TNBC中的表达,分析其与各临床病理特征的关系。结果 TNBC肿瘤细胞CD47的表达均高于NTNBC,差异有统计学意义(P0.05)。TNBC肿瘤细胞CD47阳性率为52.3%,与临床分期(P0.05)、淋巴结转移/远处转移(P0.05)和脉管侵犯(P0.05)密切相关。结论 CD47表达与TNBC的临床分期、淋巴结转移/远处转移和脉管侵犯有相关性,可以作为预后评判指标,也是潜在的免疫治疗靶点。
[Abstract]:Objective to investigate the expression of CD47 in (triple negative breast carcinoma,TNBC and its correlation with clinicopathological features. Methods 185 cases of TNBC and 35 cases of non-tri-negative breast cancer (non-triple negative breast carcinoma,NTNBC) were stained with tissue microarray and immunohistochemical Bond Polymer Refine Detection method. The expression of CD47 in TNBC was observed and the relationship between the expression of CD47 and the clinicopathological features was analyzed. Results the expression of CD47 in tumor cells of TNBC was significantly higher than that in NTNBC, (P0.05). The positive rate of CD47 in tumor cells of). TNBC was 52.3%, which was significantly higher than that in clinical stage (P0.05). Lymph node metastasis / distant metastasis (P0.05) and vascular invasion (P0.05) were closely related. Conclusion the expression of CD47 is correlated with the clinical stage of TNBC, lymph node metastasis / distant metastasis and vascular invasion. It can be used as a prognostic index and a potential immunotherapy target.
【作者单位】： 皖南医学院弋矶山医院临床病理科;芜湖市第一人民医院病理科;
【分类号】：R737.9
本文编号：2424523
[Abstract]:Objective to investigate the expression of CD47 in (triple negative breast carcinoma,TNBC and its correlation with clinicopathological features. Methods 185 cases of TNBC and 35 cases of non-tri-negative breast cancer (non-triple negative breast carcinoma,NTNBC) were stained with tissue microarray and immunohistochemical Bond Polymer Refine Detection method. The expression of CD47 in TNBC was observed and the relationship between the expression of CD47 and the clinicopathological features was analyzed. Results the expression of CD47 in tumor cells of TNBC was significantly higher than that in NTNBC, (P0.05). The positive rate of CD47 in tumor cells of). TNBC was 52.3%, which was significantly higher than that in clinical stage (P0.05). Lymph node metastasis / distant metastasis (P0.05) and vascular invasion (P0.05) were closely related. Conclusion the expression of CD47 is correlated with the clinical stage of TNBC, lymph node metastasis / distant metastasis and vascular invasion. It can be used as a prognostic index and a potential immunotherapy target.
【作者单位】： 皖南医学院弋矶山医院临床病理科;芜湖市第一人民医院病理科;
【分类号】：R737.9
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