二甲双胍对大肠癌防治作用的研究进展
发布时间：2019-02-17 10:04
【摘要】：二甲双胍是目前使用最为普遍的口服降糖药物之一,其降糖以外的抗肿瘤作用逐渐被人们认知,二甲双胍能抑制多种类型肿瘤进展,其中包括大肠癌。二甲双胍对大肠癌的防治作用主要通过以下方面:激活AMPK途径、抑制肿瘤血管生成、免疫调节、增强肿瘤细胞对化疗药物敏感性及抑制肿瘤干细胞等。长期大量实验性研究证实二甲双胍对大肠癌防治均有一定疗效,因此二甲双胍有望成为新一代抗肿瘤药物。但由于目前多数二甲双胍对大肠癌防治的临床研究均存在明显偏倚性、随机对照试验极少、循证医学依据尚且不足,因此关于二甲双胍是否应继续用于大肠癌防治的问题存在广泛争议。
[Abstract]:Metformin is one of the most commonly used oral hypoglycemic drugs. Its antitumor effects beyond hypoglycemia have been gradually recognized. Metformin can inhibit the progression of many types of tumors, including colorectal cancer. The preventive and therapeutic effects of metformin on colorectal cancer are as follows: activation of AMPK pathway, inhibition of tumor angiogenesis, immunomodulation, enhancement of tumor cell sensitivity to chemotherapeutic drugs and inhibition of tumor stem cells, etc. A large number of experimental studies have proved that metformin has a certain therapeutic effect on the prevention and treatment of colorectal cancer, so metformin is expected to become a new generation of antitumor drugs. However, most of the clinical studies on the prevention and treatment of colorectal cancer by metformin have obvious bias, and there are few randomized controlled trials and insufficient evidence based medicine. Therefore, whether metformin should continue to be used in the prevention and treatment of colorectal cancer is controversial.
【作者单位】： 遵义医学院附属医院;
【基金】：贵州省科技厅社会发展攻关项目[黔科合SY字(2011)3056号
【分类号】：R735.34
[Abstract]:Metformin is one of the most commonly used oral hypoglycemic drugs. Its antitumor effects beyond hypoglycemia have been gradually recognized. Metformin can inhibit the progression of many types of tumors, including colorectal cancer. The preventive and therapeutic effects of metformin on colorectal cancer are as follows: activation of AMPK pathway, inhibition of tumor angiogenesis, immunomodulation, enhancement of tumor cell sensitivity to chemotherapeutic drugs and inhibition of tumor stem cells, etc. A large number of experimental studies have proved that metformin has a certain therapeutic effect on the prevention and treatment of colorectal cancer, so metformin is expected to become a new generation of antitumor drugs. However, most of the clinical studies on the prevention and treatment of colorectal cancer by metformin have obvious bias, and there are few randomized controlled trials and insufficient evidence based medicine. Therefore, whether metformin should continue to be used in the prevention and treatment of colorectal cancer is controversial.
【作者单位】： 遵义医学院附属医院;
【基金】：贵州省科技厅社会发展攻关项目[黔科合SY字(2011)3056号
【分类号】：R735.34
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1 曹洋;大肠癌的中医药治疗近况[J];中国药物与临床;2002年02期
2 刘福坤;大肠癌化疗的回顾与展望[J];大肠肛门病外科杂志;2003年04期
3 王严庆;大肠癌化疗进展[J];大肠肛门病外科杂志;2003年04期
4 王志军;中药辅助大肠癌化疗的临床观察[J];甘肃科技;2003年07期
5 金海敏;李克强;孟庆勇;;胶滴肿瘤药敏检测技术在大肠癌治疗中的应用[J];浙江中医药大学学报;2008年02期
6 胡丽娟;黄绍刚;周福生;黄穗平;;中医药抗大肠癌的研究思路[J];辽宁中医药大学学报;2008年08期
7 韩力;潘永福;;大肠癌从脾论治研究进展[J];上海中医药杂志;2010年01期
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