腕踝针治疗非小细胞肺癌患者含顺铂化疗方案致呕吐的临床观察

发布时间：2019-02-24 18:26

【摘要】：目的:观察腕踝针预防含顺铂化疗后患者呕吐的临床疗效。方法:按照相关的诊断标准和样本量的计算方法,将入组的45例接受含顺铂化疗的患者按照随机数字表分为两组,对照组23例在顺铂化疗前给以标准治疗(地塞米松+托烷司琼),治疗组22例以标准治疗加腕踝针治疗,观察两组呕吐发生率、缓解率、临床症状评分及KPS评分。结果:(1)一般资料分析:随机入组后对两组年龄、BMI、舒张压、收缩压、呼吸、心率、体温、病程经两独立样本t检验,两组差异均无统计学意义(P㧐0.05)。性别、民族、过敏史、用药史、既往史、合并用药经χ2检验,两组差异均无统计学意义(P0.05)。此结果表明两组之间差异不具有统计学意义,具有一定的可比性;(2)评估临床治疗效果:(1)两组的呕吐及恶心发生率在第三天经秩和检验,P0.05,在第一、第二、第四及第五天,P0.05;(2)两组的中医证候疗效经秩和检验,P0.05;(3)两组KPS的变化经秩和检验,P0.05,得知疗效不显著;治疗组呕吐及恶心情况在第三天与对照组的差异有统计学意义(P0.05),其余四日两组间无统计学差异。结论:腕踝针在治疗顺铂引起的延迟性呕吐方面有着一定疗效,且有较高安全性。
[Abstract]:Objective: to observe the clinical effect of wrist ankle acupuncture on preventing vomiting after chemotherapy with cisplatin. Methods: according to the relevant diagnostic criteria and the calculation method of sample size, 45 patients who received cisplatin-containing chemotherapy were divided into two groups according to the randomized numerical table. The control group (23 cases) received standard treatment (dexamethasone tropisetron) before cisplatin chemotherapy, and the treatment group (22 cases) received standard therapy plus wrist ankle acupuncture. The incidence of vomiting, remission rate, clinical symptom score and KPS score were observed. Results: (1) General data analysis: there was no significant difference in age, BMI, diastolic blood pressure, systolic blood pressure, respiration, heart rate, body temperature and course of disease between the two groups after two independent samples t test (P0. 05). There was no significant difference between the two groups in sex, nationality, allergic history, medication history, past history, combined use of drugs by 蠂 2 test (P0.05). The results show that the differences between the two groups are not statistically significant and have certain comparability. (2) Evaluation of clinical efficacy: (1) the incidence of vomiting and nausea in the two groups was tested by rank sum test on the third day (P0.05), and on the first, second, fourth and fifth days, P0.05; (2) the curative effect of TCM syndromes in the two groups was tested by rank sum test (P0.05), (3) the change of KPS in the two groups was tested by rank sum test (P0.05), and it was found that the curative effect was not significant. The vomiting and nausea in the treatment group were significantly different from those in the control group on the 3rd day (P0.05), but there was no significant difference between the two groups on the other 4 days. Conclusion: wrist ankle acupuncture is effective and safe in the treatment of delayed vomiting induced by cisplatin.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2

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