结肠癌患者肿瘤微环境中T细胞亚群与肿瘤细胞转移的关系

发布时间：2019-03-19 19:33

【摘要】：目的探讨结肠癌患者肿瘤微环境中T细胞亚群与肿瘤细胞转移的关系。方法前瞻性收集该院收治的结肠癌患者89例,所有患者行结肠癌切除术,收集术中肿瘤标本,检测肿瘤组织中CD4~+T细胞、CD8~+T细胞和调节性T细胞。分析CD4~+T细胞、CD8~+T细胞及调节性T细胞与患者临床特征关系。结果随着TNM分期的增加,CD4~+T细胞和调节性T细胞增加,CD8~+T细胞降低(P0.05)。高分化、中分化及低分化患者调节性T细胞分别为(6.59±1.87)%、(7.27±1.81)%和(8.12±1.92)%,差异有统计学意义(P0.05)。合并淋巴结转移患者CD4~+T细胞增高,CD8~+T细胞降低,调节性T细胞升高(P0.05)。腺癌、黏液癌期未分化癌调节性T细胞分别为(6.82±1.88)%、(7.28±1.82)%和(8.22±1.91)%,差异有统计学意义(P0.05)。结论肿瘤微环境中T细胞亚群失衡与肿瘤细胞的转移相关,调节微环境中T细胞水平或可改善患者临床预后。
[Abstract]:Objective to investigate the relationship between T cell subsets and tumor cell metastasis in tumor microenvironment of colon cancer patients. Methods 89 patients with colon cancer treated in our hospital were prospectively collected. All patients underwent colon cancer resection. The CD4~ T cells, CD8~ T cells and regulatory T cells were detected in the tumor tissues. The relationship between CD4~ T cells, CD8~ T cells and regulatory T cells and the clinical characteristics of the patients was analyzed. Results with the increase of TNM stage, CD4~ T cells and regulatory T cells increased and CD8~ T cells decreased (P0.05). The regulatory T cells were (6.59 卤1.87)%, (7.27 卤1.81)% and (8.12 卤1.92)% in patients with high differentiation, moderate differentiation and low differentiation, respectively (P0.05). In patients with lymph node metastasis, CD4~ T cells increased, CD8~ T cells decreased, and regulatory T cells increased (P0.05). The regulatory T cells in adenocarcinoma and mucinous undifferentiated carcinoma were (6.82 卤1.88)%, (7.28 卤1.82)% and (8.22 卤1.91)%, respectively (P0.05). Conclusion the imbalance of T cell subsets in tumor microenvironment is related to the metastasis of tumor cells, and the regulation of T cell level in microenvironment may improve the clinical prognosis of patients.
【作者单位】：浙江省宁波明州医院普通外科;浙江医院检验科;
【基金】：2014年浙江省医药卫生一般研究计划(No:2014KYA003)
【分类号】：R735.35

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