HLA-DRB1等位基因与新疆地区维、汉族中晚期宫颈癌的相关性研究
发布时间：2019-03-22 10:25
【摘要】：目的:分析新疆地区维、汉族妇女HLA-DRB1等位基因频率分布情况,探索其与中晚期宫颈癌的相关联系。方法:选取100例中晚期宫颈癌患者(其中维吾尔族患者37例,汉族患者63例)及188例健康对照(其中维吾尔族健康对照97例,汉族健康对照91例),应用聚合酶反应/序列特异性引物检测HLA-DRB1等位基因,根据不同因素对基因频率进行比较,并进一步了解HLA-DRB1与宫颈癌近期疗效及预后的联系。结果:(1)汉族人群和维吾尔族人群都携带有相同的13种HLA-DRB1等位基因;(2)汉族健康对照组HLA-DRB1*01基因频率明显低于维吾尔族健康对照组,汉族健康对照组HLA-DRB1*09、HLA-DRB1*12基因频率明显高于维吾尔族健康对照组,差异均有统计学意义(P0.05);汉族宫颈癌组HLA-DRB1*07基因频率明显低于维族宫颈癌组,差异有统计学意义(P0.05)。(3)新疆地区汉族宫颈癌组HLA-DRB1*15基因频率明显高于汉族健康对照组,维吾尔族宫颈癌患者HLA-DRB1*04基因频率明显低于维吾尔族健康对照组,维吾尔族宫颈癌患者HLA-DRB1*07、HLA-DRB1*11基因频率明显高于维吾尔族健康对照组,差异均有统计学意义(P0.05)。(4)HPV16阳性组宫颈癌HLA-DRB1*12基因频率明显低于HPV16阴性组,中分化鳞癌组HLA-DRB1*04基因频率明显高于非中分化鳞癌组,52岁年龄组宫颈癌HLA-DRB1*11基因频率明显低于≥52岁年龄组,差异均有统计学意义(P0.05)(5)HLA-DRB1等位基因与宫颈癌近期疗效及预后方面未见明显联系。结论:(1)汉族人群和维吾尔族人群都携带有相同的HLA-DRB1等位基因;(2)维、汉族之间HLA-DRB1等位基因分布存在较大差异性;同一等位基因在不同民族间起着不同作用。(3)HLA-DRB1*15可能是汉族人群宫颈癌的易感基因;HLA-DRB1*07、HLA-DRB1*11可能是维吾尔族人群宫颈癌的易感基因;HLA-DRB1*04可能是维吾尔族人群宫颈癌的保护基因。(4)携带HLA-DRB1*12等位基因的宫颈癌患者可能更不易感染HPV16;携带HLA-DRB1*04等位基因的宫颈癌患者可能更易罹患中分化鳞癌;携带HLA-DRB1*11等位基因的宫颈癌患者更易在中老年阶段发病。(5)HLA-DRB1等位基因与宫颈癌近期疗效及预后方面未见明显相关性。
[Abstract]:Aim: to analyze the distribution of HLA-DRB1 allele frequency in Uygur and Han women in Xinjiang and to explore its association with advanced cervical cancer. Methods: 100 patients with advanced cervical cancer (including 37 Uighur and 63 Han) and 188 healthy controls (97 Uighur and 91 Han) were selected. HLA-DRB1 alleles were detected by polymerase reaction / sequence-specific primers, and the gene frequencies were compared according to different factors, and the relationship between HLA-DRB1 and short-term curative effect and prognosis of cervical cancer was further understood. Results: (1) 13 HLA-DRB1 alleles were found in both Han and Uygur populations. (2) the frequency of HLA-DRB1*01 gene in Han healthy control group was significantly lower than that in Uygur healthy control group, and the HLA-DRB1*09,HLA-DRB1*12 gene frequency in Han healthy control group was significantly higher than that in Uygur healthy control group. The difference was statistically significant (P0.05); The frequency of HLA-DRB1*07 gene in Han cervical cancer group was significantly lower than that in Uygur cervical cancer group (P0.05). (3). The HLA-DRB1*15 gene frequency in Xinjiang Han cervical cancer group was significantly higher than that in Han healthy control group. The frequency of HLA-DRB1*04 gene in Uighur cervical cancer patients was significantly lower than that in Uighur healthy controls, and the HLA-DRB1*07,HLA-DRB1*11 gene frequency in Uighur cervical cancer patients was significantly higher than that in Uighur healthy controls. The HLA-DRB1*12 gene frequency of cervical carcinoma in HPV16 positive group was significantly lower than that in HPV16 negative group, and the HLA-DRB1*04 gene frequency in moderately differentiated squamous cell carcinoma group was significantly higher than that in non-intermediate differentiated squamous cell carcinoma group (P0.05). (4). The frequency of HLA-DRB1*11 gene in 52-year-old group was significantly lower than that in 鈮，
本文编号：2445512
[Abstract]:Aim: to analyze the distribution of HLA-DRB1 allele frequency in Uygur and Han women in Xinjiang and to explore its association with advanced cervical cancer. Methods: 100 patients with advanced cervical cancer (including 37 Uighur and 63 Han) and 188 healthy controls (97 Uighur and 91 Han) were selected. HLA-DRB1 alleles were detected by polymerase reaction / sequence-specific primers, and the gene frequencies were compared according to different factors, and the relationship between HLA-DRB1 and short-term curative effect and prognosis of cervical cancer was further understood. Results: (1) 13 HLA-DRB1 alleles were found in both Han and Uygur populations. (2) the frequency of HLA-DRB1*01 gene in Han healthy control group was significantly lower than that in Uygur healthy control group, and the HLA-DRB1*09,HLA-DRB1*12 gene frequency in Han healthy control group was significantly higher than that in Uygur healthy control group. The difference was statistically significant (P0.05); The frequency of HLA-DRB1*07 gene in Han cervical cancer group was significantly lower than that in Uygur cervical cancer group (P0.05). (3). The HLA-DRB1*15 gene frequency in Xinjiang Han cervical cancer group was significantly higher than that in Han healthy control group. The frequency of HLA-DRB1*04 gene in Uighur cervical cancer patients was significantly lower than that in Uighur healthy controls, and the HLA-DRB1*07,HLA-DRB1*11 gene frequency in Uighur cervical cancer patients was significantly higher than that in Uighur healthy controls. The HLA-DRB1*12 gene frequency of cervical carcinoma in HPV16 positive group was significantly lower than that in HPV16 negative group, and the HLA-DRB1*04 gene frequency in moderately differentiated squamous cell carcinoma group was significantly higher than that in non-intermediate differentiated squamous cell carcinoma group (P0.05). (4). The frequency of HLA-DRB1*11 gene in 52-year-old group was significantly lower than that in 鈮，
本文编号：2445512
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